Flashcards
Hydrochlorothiazide
Cards in this deck (15)
- 1Trade namesDithiazide
- 2Therapeutic classdiuretic
- 3Pharmacological classThiazide diuretic
- 4indicationsHTN
Oedema - 5ActionIncreases sodium and water excretion by inhibiting sodium and chloride reabsorption in the nephrons distal segment.
- 6Therapeutic effectLowers blood pressure, increases water and sodium excretion
- 7Absorption50 - 60 % absorbed by the GIT
- 8DistributionCrosses the placental but not blood-brain barrier - can be found in breast milk
- 9Metabolism & excretionNot metabolised but is excreted rapidly by kidneys
- 10Half-life6- 12 hours
- 11Contraindications/precautionsContraindicated in individuals hypersensitive to other thiazide or other sulfonamide derivatives and in those with anuria.
Use cautiously in:
children and individuals with severe renal disease or impaired hepatic function. - 12Possible adverse reactionsCNS: dizziness, headache, vertigo
CV: orthostatic hypotension, dehydration
Eye: blurred vision
GI: anorexia, N + V, abdo pain, diarhhoea, constipation
GU: frequent urination, polyuria, renal failure
Metabolic: hypokalaemia, hyperglycaemia, fluid and electrolyte imbalance, gout - 13(interactions) Use withCorticosteroids can cause hypokalaemia and electrolyte depletion
Opiates can increase orthostatic hypotensive effect
Lithium can inc. risk of lithium toxicity
Insulin can dec. effect of hypoglycaemic drugs - 14Nursing assessment implicationsBlood Pressure
Monitor fluid intake and output, weight, blood pressure, serum electrolyte levels
Monitor serum creatinine and urea levels regularly
Monitor blood glucose level
Monitor blood uric acid level - 15EducationTake drug with food to minimise GI upset Take drug in morning to avoid nocturia.
Tell patients to report adverse effects and Watch for signs of hypokalemia - muscle cramps/weakness
Wear sunscreen when outdoors
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- User has deleted their subject information Flashcards on Hydrochlorothiazide , created by Deleted user on 08/06/2018.
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- Created by Em J · Jun 8, 2018
- Copied by Em J · Jun 8, 2018
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