Flashcards
Adrenergic Antagonist
Cards in this deck (26)
- 1—Phenoxybenzamine
Non-selective a-antagonist
B-haloalkylamine
Uses reactive aziridinium intermediate
Covalent irreversible inhibitor
- 2—Prazosin
Selective a1-antagonist
Quinazoline
Contains a 4-amino-6,7-dimethoxyquinazoline ring and piperazine ring
Uses: HTN, BPH
- 3—Doxazonsin
Selective a1-antagonist
Quinazoline
Contains a 4-amino-6,7-dimethoxyquinazoline ring and piperazine ring
Uses: HTN, BPH
- 4—Terazosin
Selective a1-antagonist
Quinazoline
Quinazoline ring is required for a1- antagonism
- 5—Alfuzosin
Selective a1-antagonist
Quinazoline
Open ring piperazine ring
- 6—Tamsulosin
Selective a1-antagonist
Non-quinazoline a1 blocker
BPH only (a1a blockers in prostate)
Sulfa group! Watch for allergies
- 7—Silodosin
Selective a1-antagonist
Non-quinazoline a1 blocker
BPH only (a1a blockers in prostate)
- 8—Carteolol
B-adrenergic antagonist
Aryloxypropanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma
- 9—Metipranolol
B-adrenergic antagonist
Aryloxypropanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma
- 10—Nadolol
B-adrenergic antagonist
Aryloxypropanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma
- 11—Pindolol
B-adrenergic antagonist - nonselective
Aryloxypropanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma
- 12—Sotalol
B-adrenergic antagonist nonselective
Phenethylanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma
- 13—Propranolol
B-adrenergic antagonist nonselective
Aryloxypropanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma, anxiety!
HIGH lipophilicity = CNS penetration
- 14—Timolol
B-adrenergic antagonist nonselective
Aryloxypropanolamine
Uses: HTN, arrhythmias, 2o MI protection, glaucoma
- 15—Acebutolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
More cardio-selective
Safe for lung disease patients - 16—Atenolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
More cardio-selective
Safe for lung disease patients
- 17—Betaxolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
More cardio-selective
Safe for lung disease patients
- 18—Esmolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
Cleavable ester = short half-life (8 min) - hospital use
More cardio-selective
Safe for lung disease patients
- 19—Metoprolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
More cardio-selective
Safe for lung disease patients
- 20—Bisoprolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
More cardio-selective
Safe for lung disease patients
- 21—Nebivolol
B-Adrenergic antagonist - B1 selective
Aryloxypropanolamine
Nitric Oxide potentiating effects = vasodilation and B1 effects in heart
More cardio-selective
Safe for lung disease patients
- 22—Labetalol
Mixed acting a/B- antagonist (a1, B1, B2)
Phenylethanolamine
B blocking is 1.5 x a1 blocking
- 23—Carvedilol
Mixed acting a/B- antagonist (a1, B1, B2)
Aryoxypropanolamine
B-blocking is 10-100x a1 blocking
- 24—Metyrosine
Inhibits tyrosine hydroxylase in catechol (NE) biosynthesis
R-isomer is not active
Depletes levels of DA, Epin, and NE
- 25—Carbidopa
Aromatic L-amino acid decarboxylase inhibitor in DA biosynthesis
Used as modulator of peripheral adrenergic neurotransmission
Used in combo with Levodopa for Parkinson's
- 26—Levodopa
Dopamine precursor
Used with Carbidopa to pass BBB before being broken down
Used to treat Parkinson's
Information
- Description
- Cardiology Med Chem Flashcards on Adrenergic Antagonist, created by Courtney P on 30/01/2019.
- Created by
- Courtney P
- Views
- 51
- Rating