Flashcards
Epilepsy and sleep disorders
Cards in this deck (20)
- 1What are the two major components of toothpastes?Humectants and abrasives
- 2What is the most commonly used benzodiazepine antagonist in the UK?Flumazenil
- 3What is the major predisposing factor for paradoxical effects of benzodiazepines?Alcoholism
- 4What does a simple suppository contain?Fine particles of drug suspended in a melted base
- 5What drug is first line treatment for absence seizures?Ethosuximide
- 6How does diphenhydramine cause drowsiness?It antagonises the 5-HT1A receptor in the brain
- 7What is the drug target of benzodiazepines?The GABA-A receptor
- 8What is the most common neurotransmitter?GABA
- 9What are the two most common Glutamate receptors?NMDA receptors
AMPA receptors - 10What protein does Levetiracetam target?SV2A
- 11What are the two main types of seizures?- Focal
- Generalized - 12How does carbamazepine and phenytoin work in treating epilepsy?Lowers neuronal excitability by blocking voltage gated sodium channels in the presynaptic neurons
- 13What are the two targets of Sodium Valproate?Voltage-gated sodium channels
LVA, T-type calcium channels - 14What subunit of the HVA calcium channels do pregabalin and gabapentin bind to?alpha-2 delta-1
- 15What is the mechanism of action of Felbamate?Inhibits excitatory neurotransmission by blocking NMDA receptors
- 16What two classes of drugs, used to treat epilepsy, bind to the GABA-A receptor and prolong its opening?Benzodiazepines
Barbiturates - 17What is the mechanism of action of Vigabatrin?Inhibits GABA- aminotransferase
- 18What two antiepileptics can cause hyponatremia?Carbamazepine
Oxcarbazepine - 19What two antiepileptics can cause double vision?Lamotrigine
Phenytoin - 20Name 4 side effects of sodium valproate- Sedation
- Dizziness
- Weight Gain
- Liver Toxicity