Flashcards
Complex lipids
Cards in this deck (13)
- 1Complex lipids (lips) - polar lips - POlips - glycolips- glyceroPOlips (GPOL) & sphingoPOlips (SPOL)
- glyceroglycolips (GGL) & sphingoglycolips (SGL) - 21. GPOL - general structure - X examples - simplest - nomenclature- 2 fatty acids - glycerol - PO - X (alcohol)
- H2O, ethanolamine, choline, serin etc.
- phosphatidic acid (X = 'OH)
- phophatidyl-X - 3- Ether lips- plasmalogen (vinyl ether linkage)
- X = choline or ethanolamine - 42. SPOL - general structure - E.g. sphingomyelin- just a sphingosine attached to C1 of glycerol & the rest is same
- C1 of glycerol = sphingosine
C2 of glycerol = palmitate
C3 of glycerol = POcholine - 53. GGL - general structure - X = - where abundant? - nomenclature- C3 has galactose-X attached and the rest is same
- OH or galactose
- chloroplasts
- monogalactosyl diacylglyccerol
digalactosyl diacylglycerol - 64. SGP - general structure - cerebroside - ganglioside- C1 = sphingosine, C2 = fatty acid, C3 = glucose or galactose
- gluco/galacto-cerebroside
- if C3 = chain of sugars - 7formation of membrane GPOL1. formation of phosphatidate (POT)
2a. Diacylglycerol (DAG) processing
or
2b. CDP-DAG processing - 81. POT formation (3 steps) DHAP = dihydroxyacetone PO G3P = glycerol-3-PO LPT = lysophosphatidate- DHAP + NADH ---> G3P + NAD+ by G3P dehydrogenase
- G3P + R2CO-CoA ---> LPT + CoA by GPO acyltransferase
- LSP + R2CO-CoA ---> POT + CoA
by GPO acyltransferase - 92ai. DAG processing (2 steps) TAG - triacylglycerol PO- POT + H2O ---> Pi + DG by phosphatidic acid phosphatase
- DAG + R3CO-CoA ---> CoA + TAG by DAG acyltransferase - 102aii) DAG processing (3 steps) ea = ethanolamine ct = cytidyltransferase- ea + ATP ---> PO-ea + ADP by ea kinase
- PO-ea + CTP ---> CDP-ea + PPi by CTP-PO-eact
- CDP-ea + DAG ---> CMP + POTea
by CDP-ea-1,,2-DAG-PO-ea transferase - 11Synthesis of phosphatidylserinedisplacement reaction of POT-X with serine
- 122bi. CDP-DAG processingPOT + CTP ---> PPi + CDP-DAG
- CDP-DAG + inositol ---> POT-inositol
or
- CDP-DAG + POTG ---> cardiolipin - 13breakdown of GPOL's - POlipase A1 - POlipase A2 - POlipase C - pOlipase D- cleaves C1 fatty acid
- cleaves C2 fatty acid
- cleaves Po group before phosphorus
- cleaves Po group after phosphorus
This forms lysophospholipid
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- BIOL 201: Biochemistry Flashcards on Complex lipids, created by Jumael Zafar on 13/12/2019.
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- Jumael Zafar
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