Flashcards
Antibody Response + Immunity
Cards in this deck (15)
- 1what happens in a T cell independent B-cell response?triggered by non-protein antigens (e.g. bacteria), leads to antigen receptor cross linkage on the surface of B-cells. stimulates IgM only (no class switching)
- 2what happens in a t cell dependent response?protein antigen recognised by B cells, internalised and digested, act as APC and present on MHC II, detected by TH2 and signal for class switching
- 3where do naive B cells enter lymph nodes?high endothelial venules
- 4what happens if a B cell encounters an antigen on its way to the LN follicle?B cell detects its epitope and begins to proliferate forming a primary focus (can now interact with T helper cells)
- 5what is formed whe the B cells leave the primary focus and enter a follicle??creates a germinal centre and secondary follicle
- 6where do activated B cells migrate o whn they have matured to plasma cellsmedullary cord and are secreted into efferent lymph
- 7describe the stages of a primary antibody response1. 5-7 day delay before AB production starts (LAG)
2. clonal expansion and plasma cells formed, IgM in blood (LOG)
3. class switching to IgG
4. decline - some plasma cells undeo apoptosis, some remain long term as memory cells - 8explain how a secondary response differslag phase is shorter, antibody prsists, atains a higher concentration and IgG is predominant
- 9what do naive b cells initially synthsise?IgD or IgM
- 10what signals B cells to rearrange constant genes?cytokine signals from B cells
- 11what is meant by a monoclonal response?antibodies that only recognise one epitope of one antigen
- 12what do antibodies in the serum test for?exposure to the pathogen, response to vaccination and immune mediated disease
- 13what does a ELISA detect?prescence of an antibody or antigen
- 14what triggers clonal expansion of B cells?surface imunoglobulin receptors recognise antigenic epitopes on surface of pathogens
- 15where do plasma cells synthesise AB's into?efferent lymph then reach tissues via bloodstream
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- (LYM) Flashcards on Antibody Response + Immunity, created by becki_fernandes on 02/05/2013.
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