Beta-lacatams

Beta-Lactams

Penicillins

Cephalosporins

Carbapanems

Monobactams

Indications

- Prevention and treatment of infection by gram + bacteria

- Contraindicated for allergies (Zosyn & augmentin)

Mechanisms of action

- Enter bacteria through CW

- Bind to proteins inside cell

- Disrupt normal CW synthesis

- Bactericidal

Adverse Effects

- Urticaria, pruritus, angioedema

- Avoid for anyone w/ penicillin allergies

- N/V, diarrhea

Interactions

- NSAIDs (ibuprofen) causes penicillin to be more potent

- Oral contraceptive=decreased effectiveness

- Warfafin (monitor INR & PT)

1st gen.

- Mostly gram + coverage