15666979
Description
Ahmed has
tremors
- Anatomy of
Basal Ganglia
- Physiology of
Basal Ganglia
- Parkinsonism
- Is a clinical
“syndrome”, NOT a
disease
- Clinical Features
- Clinical Features
- Include
- Parkinson Disease
- Definition
- Degenerative loss of
dopaminergic neurons
in the substantia nigra
of the basal ganglia
- Degenerative loss of
dopaminergic neurons
in the substantia nigra
of the basal ganglia
- Risk factors
- Estrogen
- Family History
- male
- Old age
- Estrogen
- Pathology of
Parkinsion
- PALLOR of the
SUBSTANTIA NIGRA
- LEWY BODIES
(alpha-synuclein protein)
- PALLOR of the
SUBSTANTIA NIGRA
- Signs &
symptoms
- Tremors
- Tremors
- Investigation
- Management
- Prognosis
- A period of 2 to 3 years when treatment
with dopaminergic agents results in
resolution of symptoms.
- After 5 years of levodopa treatment, motor
complications develop.
- Eventually, after a number of years, the emergence of
symptoms such as freezing, falling, and dementia, which do
not respond to levodopa, cause significant disability.
- Eventually, after a number of years, the emergence of
symptoms such as freezing, falling, and dementia, which do
not respond to levodopa, cause significant disability.
- After 5 years of levodopa treatment, motor
complications develop.
- A period of 2 to 3 years when treatment
with dopaminergic agents results in
resolution of symptoms.
- Causes
- Genetic causes such as lack
of GSTTT1 and the presence
of LRRK2
- Environmental
factors like Pesticides
(paraquat)
- Genetic causes such as lack
of GSTTT1 and the presence
of LRRK2
- Definition
- drug-induced parkinsonism
- where symptoms develop after taking certain
medications, such as some types of antipsychotic
medication, and usually improve once the
medication is stopped
- where symptoms develop after taking certain
medications, such as some types of antipsychotic
medication, and usually improve once the
medication is stopped
- progressive brain
conditions
- progressive
supranuclear
palsy
- multiple systems
atrophy
- corticobasal
degeneration
- progressive
supranuclear
palsy
- cerebrovascular
disease
- where a series of
small strokes cause several
parts of the brain to die
- where a series of
small strokes cause several
parts of the brain to die
- Parkinson Disease
- Is a clinical
“syndrome”, NOT a
disease
- Health seeking
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