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Recent developments in GPCR signalling
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Recent developments in GPCR signalling
Signalling pathway activated by a receptor in a cell is context specific
- In different cells in the body or in the same cell at different times, different things are happening
- Results in greater control over physiological outcome
Specific signalling is regulated by
- Adaptor proteins
- Scaffold proteins
- Play an important role in bringing receptors together with certain pathways
- Lipids (Association with rafts/lipid microdomains)
- Endocytosis
- Splicing
- Post-translational modifications
Regulation through interacting proteins
- RAMPS
- GRKs
- 7 types
- B-arrestins
- 4 types
- RGS proteins
Therapeutic potential of agonist-biased signalling
- Does μ-opioid receptor (MOR) desensitization and trafficking have any role in tolerance?
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- Undergraduate BMS 301 Mind Map on Recent developments in GPCR signalling, created by Kristi Brogden on 10/11/2014.
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- Kristi Brogden
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