70754
Description
Mind Map by aoife.lacey.1, updated more than 1 year ago
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Created by aoife.lacey.1
about 11 years ago
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Proteomics (2)
- PANCREATIC DUCTAL ADENOCARCINOMA (PDA)
- intro
- PDA accounts for 90% of all pancreatic cancers
- Pancreatic cancer is the 4th most common cause of cancer-related deaths
- 5-year survival is only 10-24%
- PDA arises from ductal cells of the pancreas
- PDA accounts for 90% of all pancreatic cancers
- Method of detection
- Laser capture microscopy
- use a laser to accurately cut out only the part of the tissue
sample that is to be analysed. e.g. te ductal cells and discard
the remaining tissue around it
- Analyse the different spots observed between diseased samples
and healthy controls using tissue array. e.g. Western blot
- Identify the spots found only in disease tissues using mass spectroscopy
- Validate the process
- tissue arrays
- linkeage analysis
- tissue arrays
- use a laser to accurately cut out only the part of the tissue
sample that is to be analysed. e.g. te ductal cells and discard
the remaining tissue around it
- Laser capture microscopy
- S100A6 (Calcylin) identified as being associated with poor survival in PDA
- intro
- PROSTATE CANCER
- intro
- Most common male cancer in the Western world
- 3rd leading cause of cancer deaths among men
- currently the diagnosis involves
- PSA measurements
- digital rectal exams
- transrectal ultrasound guided sonography
- PSA measurements
- over-diagnosis and over-treatment
- treatment based on whether disease is organ confined
- Most common male cancer in the Western world
- Detection
- literature review
- sample collection and preparation
- protein separation by 2-DE DIGE
- gel image analysis to look for any spots in diseased gel not in healthy control gel
- protein identification using MS
- Validation using MRM techniques
- Enter text here
- literature review
- intro
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