CellDeathMindMap

CellDeathMindMap

1. Apoptosis

   • Active
   • Normal physiological process
     • Fundamental process like
       • Cell Division
       • Cell Proliferation
     • Disturbances can cause
       • Cancers
       • Autoimmune diseases
       • Neurogenerative diseases
     • Takes hours
   • Removes individual cells
     • Doesn't damage neighbouring cells
     • Doesn't induce inflammation
   • Deprived of survival factors
     • Activate intracellular suicide program
     • Cells with survival signals stay alive
   • Cells
     • Have blebbed appearance
     • Shrink but don't lyse
     • Plasma membrane intact
       • Eventually bleb off

2. Necrosis

   • Passive
   • Induced by
     • Cellular injury
       • Involves cell death in groups
     • Accidental means
   • Rupture cell membranes
     • Release of
       • Cytoplasm
         • Into other tissue fluids
           • Activates inflammatory Response
       • Organelles
         • Incl. mitochondria
         • Including enzymes
           • Lactate dehydrogenase (LDH)
             • Generates ATP from glucose
             • Appears in blood after necrosis
   • Pathological process
     • Takes several days
   • Increase in volume and lyse