Flashcards
HPA - metronidazole
Cards in this deck (13)
- 1What is it?A nitromidazole antibiotic
- 2IndicationsGram-positive and Gram-negative anaerobic bacterial infections, eg B. fragilis
Protozoal infections, eg giardiasis, trichomoniasis - 3ActionMetronidazole and tinidazole are metabolised to active metabolites that are thought to interfere with DNA synthesis.
- 4Therapeutic effectsKills bacteria by interfering with synthesis of its DNA - reducing infection and therefore inflammation
- 5AbsorptionAbsorbed well in the GIT - 70 - 90% bioavailability
- 6Metabolism and excretionMetabolised (>70% ) in the liver and excreted through the kidneys
- 7DistributionExcept placenta, metronidazole penetrates well into body tissues and fluids
- 8Half-life6 -8 hours
- 9ContraindicationsContraindicated in individuals hypersensitive to drug or its components (such as parabens) or other nitromidazole derivatives
Use cautiously in individuals with history or evidence of blood dyscrasia and in those with severe hepatic disease - 10Side effectsabdominal pain, n + v, diarrhoea, metallic taste, CNS effects: dizziness, headache
Alcohol interaction: similar to disulfram can cause nausea vomiting, tachycardia SOB and flushing (avoid taking with alcohol) - 11InteractionsAlcohol - avoid use
- 12Nursing assessmentMonitor for adverse affects
BP - 13EducationTake metronidazole tablets with food to reduce stomach upset.
This medicine may make you feel dizzy or confused; avoid driving if you are affected like this.
Avoid alcohol!
Stop taking metronidazole and check with your doctor immediately if you have any numbness, tingling, pain or weakness in hands or feet.
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- User has deleted their subject information Flashcards on HPA - metronidazole, created by Deleted user on 10/06/2018.
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- Deleted user · Jun 2018
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- Jun 10, 2018
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- Created by Em J · Jun 10, 2018
- Copied by Em J · Jun 10, 2018
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