Quiz
L15 Clinical Pharmacology of Asthma
This quiz has question types that open in the usual player.
Questions in this quiz (10)
1Ventilation occurs by contraction and relaxation of respiratory muscles, and the elastic [blank_start]recoil[blank_end] of connective tissue in lungs. Any disease that [blank_start]inhibits[blank_end] elastic recoil can cause ventilation issues.
Obstructive diseases affect inspiratory rate (e.g. [blank_start]asthma, COPD[blank_end]), whereas restrictive diseases affect inspiratory capacity (e.g. [blank_start]pulmonary fibrosis[blank_end]).- Arecoil
- Binhibits
- Casthma, COPD
- Dpulmonary fibrosis
2Selectivity is defined as a 10 fold (2 log order) difference in affinity between receptor subtypes.
- ATrue
- BFalse
3Choosing a selective drug helps to reduce on-target [blank_start]side effects[blank_end]. E.g. a Beta-2 agonist will have less effect on the heart than a [blank_start]non-selective[blank_end] Beta agonist.
If excessive doses are used then selectivity will be [blank_start]overcome[blank_end] and the drug will act on other receptor subtypes. E.g. the usual inhaled dose of [blank_start]salbutamol[blank_end] for acute asthma is 100 mcg, the dose used for severe asthma is 5 mg, 50 times more, and [blank_start]tachycardia[blank_end] is expected.- Aside effects
- Bnon-selective
- Covercome
- Dtachycardia
- Esalbutamol
4Long acting beta agonists have a long half life because of their long duration of activity.
- ATrue
- BFalse
5Because the off-rate of binding is slow, long acting M-antagonists will be more potent (the dose will be lower than for short acting).
- ATrue
- BFalse
6Drugs for bronchodilation:
- Short acting beta agonists — [blank_start]salbutamol, terbutaline[blank_end]
- Long acting beta agonists — [blank_start]salmeterol, formoterol, vilanterol[blank_end]
- Short acting muscarinic antagonists — [blank_start]ipratropium[blank_end]
- Long acting muscarinic antagonists — [blank_start]glycopyrronium, tiotropium, umeclidinium[blank_end]- Asalbutamol, terbutaline
- Bsalmeterol, formoterol, vilanterol
- Cipratropium
- Dglycopyrronium, tiotropium, umeclidinium
7Side effects of bronchodilators for low dose beta agonists are an increased [blank_start]heart[blank_end] rate. Effects of high doses can include an increased heart rate, tremor, nervousness, peripheral [blank_start]vasodilation[blank_end], sleep [blank_start]disturbances[blank_end], and decreased plasma [blank_start]potassium[blank_end].
Side effects of muscarinic antagonists are an increased heart rate and a [blank_start]dry[blank_end] mouth.- Aheart
- Bvasodilation
- Cdisturbances
- Dpotassium
- Edry
8Corticosteroid (anti-inflammatory) side effects:
— Inhaled low dose < [blank_start]500[blank_end] mcg/day (budesonide equivalents) - [blank_start]oral candidiasis[blank_end]
— Inhaled high dose < [blank_start]1200[blank_end] mcg/day (budesonide equivalents) - oral candidiasis, growth [blank_start]delays[blank_end] (not certain, and minor, reversible), occasional HPA axis [blank_start]suppression[blank_end]
— Prednisone 5 mg/day, long term (>2 weeks) - [blank_start]oedema, dyspepsia, cushingoid[blank_end] symptoms.- A500
- Boral candidiasis
- C1200
- Ddelays
- Esuppression
- Foedema, dyspepsia, cushingoid
9Lung delivery from MDI:
≈ [blank_start]20%[blank_end] gets to the active locations in the lungs (bronchioles)
≈ [blank_start]50%[blank_end] deposits onto the oropharynx and can then reach the stomach and is absorbed
≈ [blank_start]30%[blank_end] either deposits to other areas or is exhaled- A20%
- B50%
- C30%
10Systemic availability from lung delivery is clinically irrelevant.
- ATrue
- BFalse
Information
- Description
- User has deleted their subject information Quiz on L15 Clinical Pharmacology of Asthma, created by Deleted user on 14/04/2019.
- Author
- Deleted user
- Language
- English
- Views
- 71
- History
- Created on 14 Apr 2019 · updated on 26 May 2019
- Tags
- Rating
- No ratings yet Rate this quiz