Quiz
L38 Background T1DM
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Questions in this quiz (4)
1Tolerance is a state of immunological unresponsiveness, and an [blank_start]adaptive[blank_end] response of lymphocytes. It exists because lymphocytes have [blank_start]self-reactive[blank_end] receptor, as receptors are formed by somatic recombination and sometimes recognise [blank_start]self-tissue[blank_end]. They must be deleted, or controlled by tolerance.
- Aself-reactive
- Bself-tissue
- Cadaptive
2Peripheral Tolerance is the mechanism for controlling self reactive cells that escaped deletion in their early stages.
• 3 ways this may occur:
1. Ignorance; lymphocytes are [blank_start]physically[blank_end] separated from low conc. self-antigen at “immune privileged sites” eg the [blank_start]brain, eye, testes, foetus[blank_end]. The sites also produce [blank_start]immunosuppressive cytokines[blank_end].
2. Anergy; antigen specific non-[blank_start]responsiveness[blank_end], a second signal needed from an [blank_start]APC[blank_end] is not there to activate [blank_start]T cell[blank_end].
3. Suppression; an active process [blank_start]mediated[blank_end] by a suppressor or regulatory lymphocyte.- Aphysically
- Bbrain, eye, testes, foetus
- Cimmunosuppressive cytokines
- Dresponsiveness
- EAPC
- FT cell
- Gmediated
3Autoimmunity is the breakdown of self tolerance.
- ATrue
- BFalse
4Diabetes is a T-cell mediated autoimmune disease.
- ATrue
- BFalse
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- User has deleted their subject information Quiz on L38 Background T1DM, created by Deleted user on 26/05/2019.
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- Created on 26 May 2019 · updated on 26 May 2019
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