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PSY14 Alcohol

Deleted user 14 questions Updated 14 Oct 2019

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Questions in this quiz (14)

  1. 1Alcohol Pharmacology
    1. Enhancement of inhibitory transmission - via [blank_start]GABA(a) Rs, GIRKs[blank_end] (G coupled K+ channels)
    2. Inhibition of excitatory transmission - [blank_start]NMDA R, ionotropic glu-Rs[blank_end]
    3. Secondary effects on [blank_start]monoamine, opioid, ACh[blank_end] systems, second messengers
    4. Effects on [blank_start]DA[blank_end] release in Nucleus Accumbens may mediate reward, dependence liability
    1. AGABA(a) Rs, GIRKs
    2. BNMDA R, ionotropic glu-Rs
    3. Cmonoamine, opioid, ACh
    4. DDA
  2. 2Alcohol PK
    • Rapid [blank_start]absorption[blank_end]
    • Dose proportional [blank_start]exposures[blank_end]
    • [blank_start]Zero order[blank_end] elimination

    Alcohol PD/Alcohol metabolism
    - Alcohol to Acetaldehyde via [blank_start]Alcohol dehydrogenase[blank_end]* and CYP2E1
    - Acetaldehyde to Acetic Acid via [blank_start]Aldehyde dehydrogenase[blank_end]
    -Acetic Acid to [blank_start]CO2 and H2O[blank_end]

    *Alcohol DH is [blank_start]rate[blank_end] limiting.
    1. Aabsorption
    2. Bexposures
    3. CZero order
    4. DAlcohol dehydrogenase
    5. EAldehyde dehydrogenase
    6. FCO2 and H2O
    7. Grate
  3. 3Factors Affecting Blood Alcohol Concentration (BAC)
    1. How much alcohol is consumed
    2. How [blank_start]quickly[blank_end] alcohol is consumed
    3. [blank_start]Body Weight[blank_end] (heavier = lower BAC, lightweight is a literal...)
    4. [blank_start]Women[blank_end] will have higher BACs than men because of lower body water content
    5. [blank_start]Food[blank_end] slows down the speed at which alcohol isabsorbed in the body, and also reduces peak BAC.
    6. [blank_start]Older people[blank_end] will have higher BACs than younger people because of lower body water content.
    7. Alcohol [blank_start]content[blank_end] (diluted vs concentrated) may affect absorption
    8. [blank_start]Drugs[blank_end] that slow down stomach emptying (e.g. opioids) will reduce peak BAC
    1. Aquickly
    2. BBody Weight
    3. CWomen
    4. DFood
    5. EOlder people
    6. Fcontent
    7. GDrugs
  4. 4BAC [blank_start]0.05[blank_end]% - drink driving limit
    BAC [blank_start]>0.10[blank_end]% - impaired perception, cognitive function, slower reaction times
    BAC [blank_start]>0.20[blank_end]% - amnesia, nausea
    BAC [blank_start]>0.40[blank_end]% - coma, death
    1. A0.05
    2. B>0.10
    3. C>0.20
    4. D>0.40
  5. 5Substance use disorders - epidemiology
    1. Alcohol abuse: [blank_start]2.6[blank_end]% prevalence, highest user group [blank_start]16–24[blank_end] years, higher in [blank_start]males[blank_end]
    2. Alcohol dependence: [blank_start]1.3[blank_end]% prevalence, highest user group 16–24 years, higher in males
    1. A2.6
    2. B16–24
    3. Cmales
    4. D1.3
  6. 6Tolerance:
    • reduction in response to a drug after [blank_start]repeated[blank_end] administration
    • receptor/second messenger [blank_start]desensitization/downregulation[blank_end]
    • acute vs chronic tolerance
    • may lead to increased intake to get desired effects

    Dependence:
    • [blank_start]compulsive[blank_end] drug-taking behavior; loss of ability to [blank_start]control[blank_end] use; intrusion into [blank_start]normal[blank_end] activities; + tolerance + withdrawal

    Withdrawal:
    • rebound [blank_start]physiological[blank_end] effects upon cessation or reduction of drug intake
    • symptoms usually [blank_start]opposite[blank_end] to those produced by drug (e.g. insomnia, anxiety - BDZs, alcohol; sedation, depression - cocaine
    1. Arepeated
    2. Bdesensitization/downregulation
    3. Ccompulsive
    4. Dcontrol
    5. Enormal
    6. Fphysiological
    7. Gopposite
  7. 7Odds of adult alcohol dependence are reduced by 10% for each year drinking onset is delayed in adolescence.
    1. ATrue
    2. BFalse
  8. 8"Types" of alcoholism:
    Type 1 (~75%):
    Genetic link [blank_start]weaker[blank_end]. Tend to start drinking heavily in [blank_start]response[blank_end] to setbacks, losses, or other outside circumstances. Equal in male and female. Tend to feel [blank_start]anxious[blank_end], shy, pessimistic, emotionally dependent. Drinking alcohol helps [blank_start]manage[blank_end] strong emotions (anxiety, depression).

    Type 2 (~25%)
    Genetic link [blank_start]weaker[blank_end]. Onset <[blank_start]25[blank_end]y. They drink [blank_start]regardless[blank_end] of what 's happening in their lives and often have a history of fights and arrests. More common in [blank_start]males[blank_end]. More sensation- and novelty-seeking, more [blank_start]impulsive[blank_end] and less [blank_start]socialized[blank_end]. Polysubstance abuse is common as part of an antisocial lifestyle.
    1. Aweaker
    2. Bstronger
    3. Cresponse
    4. Danxious
    5. Emanage
    6. F25
    7. Gregardless
    8. Hmales
    9. Iimpulsive
    10. Jsocialized
  9. 9Marketing and advertising normalizes and maintains a heavy drinking culture.
    1. ATrue
    2. BFalse
  10. 10As alcohol price descreases, alcohol use increases.
    1. ATrue
    2. BFalse

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User has deleted their subject information Quiz on PSY14 Alcohol, created by Deleted user on 14/10/2019.
Author
Deleted user
Language
English
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31
History
Created on 14 Oct 2019 · updated on 14 Oct 2019
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