Exam 2: Thiazolidinediones

Exam 2: Thiazolidinediones

1. Pharmacological action

   • Decrease insulin resistance
     • In turn increases sketeletal muscle and adipose tissue uptake
   • Decrease liver glucose production

2. Pharmacokinetics

   • Metabolized in liver
   • Excreted via feces (mostly) and urine

3. Adverse effects

   • Unintended ovulation
   • Bladder cancer
   • Fluid retention
   • Increased cholestrol
   • Risk for bone fracture
   • URIs/ sinusitis
   • Headaches
   • Muscle aches

4. Contraindications

   • Liver impairment
   • Bladder cancer
   • Heart failure

5. Drug interactions

   • Insulin
     • Fluid retention
     • Hypoglycemia
   • Hypoglycemia
     • Gemfibrozil
     • Coenzyme Q10
     • Ketoconazole
     • Chromium

6. Extra information

   • Also known as glitazones
   • Pioglitazone is a medication in this category

7. Nursing interventions

   • Liver Function Tests at baseline & every 3-6 months