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PHSI3012 09-2 Vascular Inflammation

Michael Jardine 8 questions

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Questions in this quiz (8)

  1. 1The following are key inflammatory proteins involved in the initiation of atherosclerosis.
    1) Selectins;
    2) Chemokines (and Chemokine receptors);
    3) Integrins;
    4) CAMs.
    What are CAMs?
    1. ACell Adhesion Molecules
    2. BChemokine Adhesion Molecules
    3. CCell Adherance Molecules
    4. DChemokine Adherance Molecules
  2. 2Selectins are a family of 3 C-type lectins expressed exclusively by bone marrow-derived cells and endothelial cells. They include which of the following types?
    1. AL (Leukocyte) – selectin
    2. BE (Endothelial) – selectin
    3. CP (Platelet + Endothelial) – selectin
    4. DE (Epithelial) – selectin
    5. EP (Platelet + Epithelial) – selectin
    6. FM (Mesenchymal) – selectin
    7. GM (Myokine) – selectin
  3. 3Which of the following are key SELECTIN ligands?
    1. APSGL1
    2. BESL-1
    3. CCD34
    4. DCD44
    5. ECD46
    6. FCD36
    7. GVCAM-1
    8. HICAM-1
    9. ITNF
    10. JCSF
  4. 4Integrins are membrane-bound proteins that are key inflammatory proteins. They’re heterodimers with α and β subunits. They include αLβ2, VLA-1, α4β1, LFA-1. Three integrin conformations have been described (bent form with closed headpiece; extended form with closed headpiece; extended form with open headpiece). Of these, the [blank_start]__________[blank_end] is the only one with HIGH affinity for ligand.
    They can be activated by either chemokine engagement or selectin engagement. One results in rolling SLOWING, the other in it STOPPING. Which stops it? [blank_start]__________[blank_end].
    1. ABent with closed headpiece
    2. BExtended with closed headpiece
    3. CExtended with open headpiece
    4. DChemokine engagement
    5. ESelectin engagement
  5. 5CAMs include Intercellular (ICAM) and Vascular (VCAM). (and others)
    [blank_start]__________[blank_end] is predominantly expressed on endothelial cells, but is also present on SMCs. Binds to VLA1 (Very Late Antigen-1) and α4β1 integrins.
    [blank_start]__________[blank_end] is expressed on endothelial cells but also on leukocytes including neutrophils and monocytes.
    Both are produced by inflammation but [blank_start]__________[blank_end] is more constitutively expressed
    1. AVCAM-1
    2. BICAM-1
    3. CICAM-1
    4. DVCAM-1
    5. EICAM-1
    6. FVCAM-1
  6. 6Three forms of cell death are described. Which is which?
    [blank_start]__________[blank_end] = “dead body”;
    [blank_start]__________[blank_end] = “eating of self”;
    [blank_start]__________[blank_end] = “falling off”.
    1. ANecroptosis
    2. BAutophagy
    3. CApoptosis
  7. 7TRAIL = Tumour necrosis-factor Related Apoptosis-Inducing Ligand.
    It’s a member of the [blank_start]__________[blank_end] ligand family.
    Causes apoptosis of cancer/tumour cells; in clinical trials for cancer therapy. Emergence of non-apoptotic functions in normal cell.
    1. ATNF
    2. BNFKB
    3. CICAM-1
    4. DVCAM-1
    5. EPSGL1
    6. FESL-1
    7. GELS-1
  8. 8Trail-/- (complete knockout) mice develop PVD and have [blank_start]__________[blank_end] vascularity in reponse to ischaemia.
    1. AImpaired
    2. BRestored

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PHSI3012 09-2 Vascular Inflammation (T2L8)
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