Quiz
Oncology Final MCQs 1- 5th Year PMU
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Questions in this quiz (100)
1EGF-(R) = [blank_start]Epidermal Growth Factor[blank_end] (Receptor)
ER = [blank_start]Estrogen Receptor[blank_end]
HER = [blank_start]Human Epidermal Receptor[blank_end]
HPV = [blank_start]Human PapillomaVirus[blank_end]
PR = [blank_start]Progesterone Receptor[blank_end]
VEGF (R) = [blank_start]Vascular Epidermal Growth Factor[blank_end] (Receptor)
TKI = [blank_start]Tyrosine kinase Inhibitor[blank_end]
ALK = [blank_start]Anaplastic lymphoma kinase[blank_end]
CRC = [blank_start]Colorectal carcinoma[blank_end]
MCA = [blank_start]Monoclonal antibody[blank_end]- AEstrogen Receptor
- BHuman Epidermal Receptor
- CHuman PapillomaVirus
- DProgesterone Receptor
- EVascular Epidermal Growth Factor
- FEpidermal Growth Factor
- GTyrosine kinase Inhibitor
- HAnaplastic lymphoma kinase
- IColorectal carcinoma
- JMonoclonal antibody
2According to WHO data by 2030, malignancies will be the leading cause of mortality. What place do they occupy now?
- Athird
- Bfourth
- Csecond
- Dfirst
3Which are the most often occurring tumors in children up to 10 years of age?
- Aneuroblastoma, leukemias, gastrointestinal tumors
- Bacute leukemias, brain tumors, Wilms tumor
- Cretinoblastoma, nephroblastoma, gastrointestinal tumors
- Dlymphomas, leukemias, brain tumors
4What are the most common neoplasias in the 2nd and 3rd decades of life?
- Asoft tissue tumors, testicular carcinoma
- Bmesenchymal tumors, breast cancer
- Cgastrointestinal tumors, osteosarcoma
- Dlung cancer, head and neck tumors
5What are the most common neoplasias in the 3rd and 4th decades of life?
- Afemale genital tract tumors, male genital tract tumors
- Bbreast cancer, uterine cancer, CRC
- Clung cancer, breast cancer, CNS tumors
- Dhead and neck tumors, sarcomas
6What are the most common neoplasias after the 5th decade of life?
- ALung carcinoma, prostate gland carcinoma
- BTumors of GIT, bladder carcinoma
- CCRC, prostate and lung carcinoma
- DHead and neck tumors, lung cancer
7There are differences In cancer morbidity and mortality between males and females. What is the gender predominance of CRC and stomach cancer?
- AMen
- BWomen
- CThere is no gender predominance
- DAge-based sex division
8Depending on geographic latitudes there is differential endemic Spread of neoplasms. Gastric carcinoma occurs predominantly in:
- AUSA, Europe, Japan
- BAsia, Europe
- CLatin America, Eastern Europe, Japan
- DSoutheast Asia and Africa
9CRC occurs with the highest frequency in:
- AEurope
- BAsia
- CThe USA
- DAustralia and New Zealand
10Mammary carcinoma is rare in:
- AThe United States, Asia
- BEurope, Latin America
- CAfrica, Asia
- DAustralia and New Zealand
11The Epstein-Barr virus is associated with infectious mononucleosis nasopharyngeal carcinoma, and Burkitt's lymphoma. The latter has marked endemic spread:
- AThe Scandinavian countries, Mongolia
- BMalaysia, Uganda, New Guinea
- CJapan, the Philippines
- DAustralia and New Zealand
12What is screening?
- Atesting a group of people for the detection of early-stage cancers
- Bexamining a group of people when certain symptoms and complaints are present
- Cdetection of unplanned disease by tests and procedures that can be applied quickly
- Devidence of disease’s initial symptoms
13What types of cancer screenings are available?
- ALung carcinoma, colon carcinoma, breast cancer
- BCRC, prostate, stomach
- CBreast cancer, prostate, cervical carcinoma
- DCRC, breast cancer, lung carcinoma
14Which of the following cancers affect predominantly men
- Alung, prostate, colorectal carcinoma
- Bmelanoma, pancreas, lung
- Ccolon, prostate, melanoma
- Dlung, pancreas, brain
15Which tumors in women confer the lowest five-year survival rate?
- Abreast
- Bovary
- Ccorpus uteri
- Dlung
16Areas with the highest oncological morbidity at present are
- AAmericas
- BEurope
- CAfrica
- DEurope and Americas
17Which tumors in males confer the lowest five-year survival rate?
- Atesticular carcinoma
- Blung cancer
- Cprostate cancer
- Dcolon cancer
18The most common Malignant tumor in Women is
- AMammary Carcinoma
- BCervical Carcinoma
- CSkin carcinoma
- DOvarian Carcinoma
19What is the most accurate definition of carcinogenesis?
- AThe occurrence of mutations in more than one locus leading to the appearance of a transformed cell
- BMultistage and prolonged process leading to transformed cells with subsequent clonal selection and expansion
- CMultistage process of transformation and development of neoplastic clone
- DThere is no correct answer
20Tumorigenesis occurs in three stages
- AProliferation, promotion, metastasis
- BInitiation, promotion, proliferation
- CProliferation, promotion, progression
- DAll answers are correct
21Neoangiogenesis
- Athe ability of cancer cells to metastasize via the blood and to form new vessels
- Buncontrolled growth of tissue that can deliver distant metastasize via the blood and the lymphatics
- Cuncontrolled development of tissue with the ability to grow and metastasize by forming new vessels
- Dthere is no correct answer
22Key features of the tumor cell are
- Aability to proliferate, metastasize, form new vessels and the possibility of apoptosis, invasion
- Bloss of apoptosis, endless division, invasion and metastasis
- Cgenerates signals for growth and development, ability to form new vessels and metastasize via the blood
- Dall answers are correct
23What is the definition of benign tumors?
- Avarying degrees of cellular and structural differentiation, do not metastasize
- Bhighly differentiated tumors whose cells resemble those from which they originated
- Ca high degree of cell differentiation, the presence of functional activity and metastatic ability
- Danswers a+c
24Which statement about malignant tumors is wrong?
- Avarying degrees of cell differentiation and structural organization
- Bcells are organized in monolayers with signs of anaplasia
- Chave an infiltrative growth
- Dthere is no correct answer
25What is relapse?
- Aa newly emerging tumor
- Bthe reappearance of a tumor following its surgical removal
- Cthe appearance of a tumor at the same site as the one removed
- Dthe appearance of regional lymph nodes
26Malignant tumors have infiltrative growth, cellular atypism, are encapsulated capsule and have the ability to give regional and distant metastases.
This statement is- Atrue
- Buntrue
- Cincomplete
- Dambiguous
27Mesenchymal tumors metastasize
- AVia lymphatics
- BVia blood
- CCanalicularly
- DIntracavitary
28The tumors of __________ metastasize in Intravascular fashion
- Alung, stomach, intestine
- Bovaries, uterus, bladder
- Chead and neck, lung and prostate
- Dthere is no correct answer
29Which of the following statements are characteristic of the cancer cell biology
- Acellular "immortality"
- Bangiogenic ability
- Caltogether
- Dability to invade and metastasize
30Indicate which factors are associated with tumor progression
- AIL-1, IL-6, TNF-α
- BEGF / R, VEGF / R, HER-2, PDGF
- COPG, RANK, RANKL
- Da+b
31Paraneoplastic syndrome is due to
- Atumor progression
- Bectopic secretion of hormone-like peptides and immune response to the tumor
- Cmetastasis
- Dthe intoxication of the organism
32Which tumors are hormone-dependent in their development
- Abreast carcinoma
- Bcolon carcinoma
- Cendometrial carcinoma
- Dall listed
33Genetic changes leading to carcinogenesis are
- ASpontaneous mutations in cell cycle regulating genes
- BMutations in genes regulating the replication and repair of DNA
- CMultiple mutations
- DAll answers are correct
34Characteristics of neoplastic cells are
- Aloss of apoptosis
- Bhigh proliferative potential
- Ctendency for invasion
- Deach indicated
35The most common primary brain tumors are
- Aanaplastic astrocytomas
- Bglioblastomas
- Coligodendrogliomas
- Dthere is no true answer
36The mean survival rate for malignant CNS tumors is
- A5-10 months
- B15-18 months
- C2 years
- DOne year
37A radical method for the treatment of solitary («3 cm) CNS tumors is
- Aradiotherapy of the brain
- Bradiosurgery
- Coperative treatment
- Dchemotherapy
38Radiation is an important part of the complex treatment.
The total dose of craniotherapy is- A40 Gy
- B60 Gy
- C80 Gy
- DThere is no true answer
39Chemotherapy incorporates
- ACisplatin
- BGemcitabine
- CTemozolamide
- DThere is no true answer
40Medulloblastoma is predominantly located in the rear cranial well and occurs most commonly in
- AThe 3rd and 4th decades of life
- BChildhood
- C2nd and 3rd decade of life
- DNewborns
41The main methods of diagnosis and follow-up of treatment effect in CNS tumors are
- ACT and MRI
- BMRI and PET scan
- CCT and PET scan
- DAll answers are correct
42Symptomatic therapy in CNS tumors includes
- Adexamethasone, tranquilizers, diuretics
- Banxiolytics, diuretics
- Canticonvulsants, diuretics, dexamethasone
- Dall answers are correct
43Brain metastases are yielded most commonly by
- AProstate and lung carcinoma
- BThyroid and gastric carcinoma
- CCarcinoma of the mammary gland and lung carcinoma
- DKidney and GIT carcinoma
44Which treatment method will be preferred for solitary brain metastasis
- ABrachytherapy
- BPercutaneous external irradiation
- COperational extirpation
- DRadiosurgery
45Temozolamide used to treat brain tumors belongs to which group of cytostatics based on its mechanism of action
- Aanthracycline
- Bantimetabolite
- Can alkylating agent
- Datyrosine kinase inhibitor
46Methods for the treatment of multiple brain metastases are
- Asurgery
- Bradiotherapy
- Cchemotherapy
- Db+c
47List the symptoms of increased intracranial pressure
[blank_start]Altered[blank_end] behaviour
[blank_start]Blurred vision[blank_end]
Feeling less alert than usual
[blank_start]Headache[blank_end]
Lack of energy or sleepiness
[blank_start]Vomiting[blank_end]
Weakness or problems with moving or talking- AAltered
- BBlurred vision
- CHeadache
- DVomiting
48Risk factors for head and neck tumors are
- Achronic etilism, 3rd and 4th decade of life, male Sex, tobacco chewing
- Bsmoking, systemic use of alcohol and mutation in p53 gene
- Cfemale sex, smoking, alcohol abuse
- Dall answers are correct
49The most common head and neck tumors metastasize
- AVia lymphatics
- BVia blood
- CRef. a+b
- DNeighborhood invasion/ local invasion
50Head and neck tumors occur with the highest frequency at which anatomic sites
- AThe oral cavity
- BOropharynx
- CLarynx
- DSinus
51The characteristic clinical picture includes
- Apain, fever, soore, difficulty swallowing
- Bulcer. dysphagia, otalgia
- Cdysphagia, dyspnoea, swelling in the neck, soor
- Dall answers are correct
52The most common histology of head and neck tumors is
- Aadenocarcinomas
- Bepidermoid carcinomas
- Csquamous cell carcinomas
- Dthere is no true answer
53A leading treatment approach for head and neck tumors is
- Aradiotherapy
- Bchemotherapy
- Cchemoradiotherapy
- Dall answers are correct
54The most common early radiation reactions are
- Adysphagia and oropharyngeal mucositis
- Breduced hearing and odinophagia
- Clarynx edema
- Da+c
55Late radiation complications are
- Atrismus, reduced hearing
- Boropharyngeal mucositis and dysphagia
- Cradiographic fibrosis
- Da+c
56The gold standard for nasopharyngeal carcinoma is
- Asurgery, radiation, chemotherapy
- Boperative intervention and subsequent radiotherapy
- Ccombined chemoradiotherapy
- Dall the options listed
57Targeted therapy for head and neck tumors is performed with
- ABevacizumab
- BCetuximab
- CPanitumumab
- DNivolumab
58HPV is related to the etiology of
- Acervical carcinoma
- Banogenital carcinoma
- Chead and neck carcinoma
- Dall listed
59Head and neck tumors include neoplasia originating from anatomical locations
- Asalivary glands, larynx, pharynx, oral cavity, nasal cavity, maxillary, frontal, ethmoidal, sphenoidal sinus
- Blarynx, pharynx, oral and nasal cavities, parotid gland
- Cparotid gland, larynx, pharynx, oral cavity, nasal cavity, paranasal sinuses
- Dparotid gland, larynx, pharynx, oral cavity, nasal cavity, maxillary, frontal, ethmoidal sinus
60Tumors of head and neck are characterized by
- Aincreased frequency in Central Asia
- Bmainly affect female subjects
- Cmost common in the western world
- Da+b
61Complete the term against the relevant definition of premalignant lesions that are associated with the development of squamous cell carcinoma:
[blank_start]Leucoplakia[blank_end] - hyperkeratosis + underlying epithelial hyperplasia
[blank_start]Erythroplakia[blank_end] - superficial erythema spots near to normal mucosa due to epithelial dysplasia- ALeucoplakia
- BErythroplakia
62The therapeutic approach to advanced disease includes
- Aprotocols with combined modality (radiochemotherapy)
- Bradical surgery
- Cadministration of platinum-based chemotherapy protocol
- Dthe combined use of surgery radiotherapy
63The four major histological types of lung carcinoma are
- Alarge cell, squamous, papillary, small cell
- Bsmall cell, squamous cell, adenocarcinoma, large cell
- Cspinocellular, acinar, small cell, large cell
- Dthere is no correct answer
64Which histological type has the worst prognosis?
- Aspinocellular
- Bacinar adenocarcinoma
- Csmall cell
- Dthere is no true answer
65What are the principal biomarkers for NSCLC?
- AEGFR, HER-2
- BK-RAS, HER-2
- CALK, PDL-1
- DEGFR, ALK, PDL-1
66The standard for ChTh in radically operated patients with NSCLC is
- AAPCT containing taxane
- BAPCT containing cisplatin
- CAPCT containing vinorelbine
- DAPCT containing anthracyclines
67Target therapies for NSCLC include
- ABevacizumab, Panitumumab, Nivolumab
- BErlotinib, Gefitinib, Crizotinid
- CPertuzumab, Cetuximab, Pembrolizumab
- DThere is no true answer
68Malignant Mesothelioma is characterized by (one wrong answer)
- AThe main method of treatment is chemotherapy
- BOrigin from the pleura, pericardium, peritoneum, testicular envelopes.
- CA causal relationship with exposure to asbestos
- DThere are a large percentage of patients with five years of survival
69Which of the following statements about lung carcinoma is NOT correct
- Amore prominent for developed countries
- Bthe main cause of cancer morbidity and mortality in women
- Cthere are 2 major histological types - small cell and non-small cell
- Dhas a high-sensitivity tumor marker for diagnosis
70Which of the following statements for small cell lung cancer (SCLC) compared to non-small cell lung cancer (NSCLC) is true
- ASCLC is more radiosensitive
- BSCLC is less chemosensitive
- CSCLC is more likely to have a peripheral localization in the lung
- DTendency towards early and rapid metastasis
7173 years old man has an increasing pain in the lumbar segment of the spine, more pronounced at bedtime. From the history - a long-standing hypertonic; sometimes smokes 1-2 cigarettes a week. Physical status is normal. Laboratory studies have found elevated serum alkaline phosphatase levels. From radiograph of the lumbar segment - a lytic bone lesion of the third lumbar vertebra.
Which of the following cancers is the most likely diagnosis:- Acarcinoma of the stomach
- Bnon-small cell lung carcinoma
- Csarcoidosis
- Dmesothelioma
72Immunotherapy in lung carcinoma is performed with
- ABCG vaccine
- BImmunomodulators
- CNivolumab, Pembrolizumab
- DThere is no true answer
73Pulmonary carcinoma metastasizes most often in
- Aliver
- Bpleura and mediastinal lymph nodes
- Cbrain
- Dbones
74The recommended behavior of a General Practitioner in a patient with a blood clot is
- AFollow-up for one month
- BX-ray and consultation with a pneumologist no later than two weeks
- CCT scan
- DX-ray and surgery referral
75What is the significance of EGFR expression Studies, KRAS mutation and ALK in non-small cell lung carcinoma
- AThey are prognostic markers for survival
- BReference markers for surgery
- CEGFR-TKI response markers
- DPossibility for personalized treatment
76Which factors are not carcinogens for lung cancer
- ASmoking
- BRadiation
- CA diet rich in fat
- DAvitaminoses
77Hypertrophic pulmonary osteoarthropathy is
- ASymptom of Peak Lung Cancer Symptom
- BComplication of radiotherapy
- CParaneoplastic syndrome in lung carcinoma
- DParaneoplastic syndrome in ovarian cancer
78Contemporary molecular genetic tests on lung cancer biopsy specimen include
- AEGFR mutation
- BPDF
- CALK
- DAll answers are correct
79Peripheral lung lesions suspect for carcinoma are indicated for further diagnostic testing with
- ASurgical resection
- BTransthoracal needle biopsy
- CBronchoscopy
- DMediastinoscopy
80For pleural effusion suspicious of lung carcinoma indicated is
- AX-ray and consultation with a pulmonologist
- BVATS (video-assisted thoracoscopy) with a biopsy
- CMagnetic resonance tomography
- DPositron emission tomography
81Palliative therapy in lung cancer is
- Aassociated with a high risk of fatal toxicity
- Bassociated with increased life expectancy at reduced quality of life
- Cfollowed by a 1 year life expectancy at improved quality of life
- Ddoes not change life expectancy
82Which statement is true for Luminous type A?
- AER, PR- positive, HER2- negative, low Ki 67
- BER PR- positive, HER2-positive, low Ki 67
- CER, PR- positive, HER2- negative, high Ki 67
- DThere is no correct answer
83Which statement is wrong for Luminous Type B?
- AER, PR- positive, HER2- negative, high Ki 67
- BER, PR- positive, HER2- overexpression, regardless of Ki 67
- CER, PR- positive, HER2- positive, low Ki 67
- DNo wrong answer
84In non-luminous type we observe?
- AER, PR- negative, HER2- overexpression
- BER, PR- positive, HER2-positive, Ki 67 low
- CER, PR- positive, HER2- negative
- DThere is no correct answer
85Genetic mutations in breast carcinoma are
- ABRCA 1, BRCA 2
- BBRCA1, BRCA2, p53
- CALK, PDL 1
- DAll listed
86Standard treatment for luminal type A breast carcinoma includes
- Achemotherapy
- Bhormone therapy
- Chormone therapy +/- chemotherapy at positive lymph nodes
- Dthere is no true answer
87Standard treatment for luminal type B HER 2 negative breast carcinoma includes
- Achemotherapy
- Bhormone therapy
- Chormone therapy +/- chemotherapy
- Dall answers are correct
88Standard treatment for luminal type B HER 2-positive breast carcinoma includes
- Achemotherapy, anti-HER 2 therapy
- Bchemotherapy, hormone therapy, anti- HER 2 therapy
- Chormone therapy, chemotherapy
- Dthere is no true answer
89Treatment in triple negative breast carcinoma includes
- Achemotherapy
- Bhormone therapy
- Cchemotherapy + hormone therapy
- Dchemotherapy, hormone therapy, anti- HER2
90Specify the standard treatment algorithm for breast cancer T2N1M0 without hormonal expression
- APCT, surgery, radiotherapy
- BSurgery, PCT, radiotherapy
- CRadiotherapy, surgery, PCT
- DThe three answers are correct
91Specify the main tumor marker for diagnosis of breast cancer
- ACEA
- BCA 15-3
- CHGT
- DCA 19-9
92The biological characteristic of the "triple-negative" breast cancer requires (choose one wrong answer)?
- Amaximum severity of therapeutic behavior
- Bhormonal therapy
- Cstrict monitoring due to the risk of early relapse and metastasis
- Daffects younger women
93Indicate which target drugs are used in HER positive breast cancer
- AAvastin, Panitumumab, Cetuximab
- BHerceptin, Lapatinib, Perjeta
- CTarceva, Iressa, Avastin
- DHerceptin, Nivolumab, Crisotinib
94A method of early detection (screening) of breast cancer is
- AEchography
- BMammography in 2 projections
- CCT
- DMRI
95The default markers for breast cancer are
- AThe total CEA and CA 15-3
- BHER, estrogen and progesterone receptors, Ki 67
- CTotal CEA and CA 125
- DSerum alkaline phosphatase and LDH
96In which % of cases the breast cancer has a genetic predisposition
- A5%
- B10%
- C25%
- D40%
97Triple-negative breast cancer belong to which of the listed histological groups?
- ALuminal A
- BLuminal B
- CBasal-like
- D"Normal" -like
98A recommended age group to start screening for early detection of breast carcinoma is
- Awomen over 60 years of age
- Bwomen over 50 years of age
- Cwomen aged 50-69
- Dfamily-related women, regardless of age
99All of these factors are associated with a decreased risk of developing breast cancer except for
- ANegative history of breastfeeding
- BFirst pregnancy before 18 years of age
- CMen after 15 years of age
- DNatural menopause before 42 years of age
100Which of the following features is associated with an unfavorable prognosis for breast carcinoma
- AER+
- BLow proportion of S-phase cells
- COverexpression of erbB2 (HER-2)
- DPR+
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- Oncology Final MCQs- 5th Year PMU Topics- Epidemiology, Carcinogenesis, CNS Tumors, Malignant head and neck Tumors, Malignant lung diseases, Malignant diseases of the mammary gland
- Author
- Med Student
- Language
- English
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