Quiz
Pharmacology XIV
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Questions in this quiz (21)
1The therapeutic effect of the salicylates is explained on the basis of the ability of the drug to
- AA) Activate autonomic reflexes
- BB) Uncouple oxidative phosphorylation
- CC) Inhibit the synthesis of prostaglandins
- DD) Competitively antagonize prostaglandins at the receptor site
2The mechanism of the antipyretic action of salicylates probably results from
- AA) Inhibition of prostaglandin synthesis in the CNS affecting hypothalamic temperature regulation
- BB) Inhibition of bradykinin in the periphery leading to sweating
- CC) Depression of oxidative enzymes leading to decreased heat production
- DD) Suppression of cholinergic mediators in the hypothalamus
- EE) Stimulation of norepinephrine in the hypothalamus
3The antipyretic action of salicylates is explained in part by
- AA) Analgesia leading to sedation
- BB) Increased blood flow through the hypothalamus
- CC) Cutaneous vasodilation leading to increased heat loss
- DD) Depression of oxidative processes leading to decreased heat production
4The locus of action of aspirin’s central antipyretic effect is the
- Aa. Brain stem
- Bb. Hypothalamus
- Cc. Basal ganglia
- Dd. Limbic system
- Ee. Cerebral cortex
5A patient who has been taking large quantities of aspirin might show increased postoperative bleeding because aspirin inhibits
- Aa. Synthesis of thromboxane A2 and prevents platelet aggregation
- Bb. Synthesis of prostacyclin and prevents platelet aggregation
- Cc. Synthesis of prostaglandin and prevents production of blood platelets
- Dd. Thrombin and prevents formation of the fibrin network
- Ee. G.I. absorption of vitamin K and prevents synthesis of blood clotting factors
6Anti-inflammatory agents, such as aspirin, interfere with hemostasis by
- Aa. Activating antithrombin
- Bb. Preventing vasoconstriction
- Cc. Inhibiting thrombin generation
- Dd. Inhibiting platelet aggregation
- Ee. Inhibiting polymerization of fibrin
7Which of the following anti-inflammatory agents does NOT act primarily by inhibiting activity of prostaglandin synthetase?
- Aa. Diflunisal
- Bb. Ibuprofen
- Cc. Triamcinolone
- Dd. Oxyphenbutazone
- Ee. Acetylsalicylic acid
8A nonsteroidal, anti-inflammatory agent that appears to produce fewer gastrointestinal disturbances than high does of aspirin is
- Aa. Ibuprofen
- Bb. Probenecid
- Cc. Pentazocine
- Dd. Acetaminophen
- Ee. Phenylbutazone
9Prolonged use of which of the following drugs does NOT cause a predisposition to gastric irritation and bleeding?
- Aa. Phenytoin
- Bb. Ibuprofen
- Cc. Indomethacin
- Dd. Phenylbutazone
- Ee. Acetylsalicylic acid
10Each of the following agents has been associated with gastric irritation EXCEPT
- Aa. Aspirin
- Bb. Alcohol
- Cc. Ibuprofen
- Dd. Indomethacin
- Ee. Acetaminophen
11Which of the following is NOT produced by excessive doses of acetylsalicylic acid?
- Aa. Delirium
- Bb. Tinnitus
- Cc. Hypothermia
- Dd. Hyperventilation
- Ee. Metabolic acidosis
12All of the following are pharmacologic and toxicologic properties of aspirin EXCEPT
- Aa. Tinnitus
- Bb. Analgesia
- Cc. Salicylism
- Dd. Antipyresis
- Ee. Suppression of the immune response
13Therapeutic effects of aspirin include
a. Analgesia
b. Tranquilization
c. Pyretic action
d. Anti-inflammatory action
e. Antirheumatic action- AA) (a), (b) and (c)
- BB) (a), (c) and (d)
- CC) (a), (d) and (e)
- DD) (b), (c) and (d)
- EE) (b), (d) and (e)
14All of the following are pharmacologic or toxicologic properties of acetylsalicylic acid EXCEPT
- Aa. Tinnitus
- Bb. Analgesia
- Cc. Antipyresis
- Dd. Methemoglobinemia
- Ee. Inhibition of prostaglandin synthesis
15All of the following are possible effects of aspirin EXCEPT
- Aa. Reduction of fever
- Bb. Shortening of bleeding time
- Cc. Suppression of inflammatory response
- Dd. Bleeding from the gastronintestinal tract
- Ee. Increase in the renal excretion of uric acid at high doses
16Of the following, aspirin does NOT cause
- Aa. Occult bleeding
- Bb. Nausea and vomiting
- Cc. Acid-base disturbance
- Dd. Suppression of the cough reflex
- Ee. Decreased tubular reabsorption of uric acid
17Which of the following is NOT true regarding acetaminophen?
- Aa. It has antipyretic properties
- Bb. It may induce methemoglobinemia
- Cc. It can be combined with codeine
- Dd. It has anti-inflammatory properties
- Ee. It is not cross-allergenic with aspirin
18The most prominent acute toxic effect associated with acetaminophen use is
- Aa. Hemorrhage
- Bb. Renal necrosis
- Cc. Hepatic necrosis
- Dd. Gastric ulceration
- Ee. Respiratory alkalosis
19Which of the following anti-inflammatory agents does NOT act primarily by inhibiting the activity of cyclooxygenase?
- Aa. Ibuprofen
- Bb. Diflunisal
- Cc. Prednisone
- Dd. Indomethacin
- Ee. Phenylbutazone
20Which of the following is the most appropriate drug to use to lower fever in a child under 12?
- Aa. Aspirin
- Bb. Ibuprofen
- Cc. Acetaminophen
- Dd. Salicylate
- Ee. Diflunisal
21Which analgesic from the following list has the longest half-life?
- Aa. Acetaminophen
- Bb. Aspirin
- Cc. Diflunisal (Dolobid)
- Dd. Ibuprofen
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- Praxis Tests: Pharmacology Quiz on Pharmacology XIV, created by ACAPUN INSTITUTE on 08/11/2021.
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- ACAPUN INSTITUTE
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