Quiz
Data Analysis
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Questions in this quiz (25)
1What is done in pairwise alignment?
- ATwo sequences are stuck on top of each others and the common areas lined up
- BTwo sequences are aligned from the beginning and their similarity analysed
- CTwo sequences are aligned and their similarity analysed
2Local alignment assigns correspondences to all residues in the sequence, leaving gaps if necessary
- ATrue
- BFalse
3The image shows which of the following?
- AAn indel
- BA mismatch
4The image shows a mismatch
- ATrue
- BFalse
5What can sequence identity be used for?
- ADNA sequence
- BAmino acid sequence
- CGene sequence
6Sequence identity can be how specific?
- AGlobal
- BLocal
7What are GAPS?
- ASpaces in part of the sequence that allows other areas to align better
- BAreas with a high density of indels
- CProteins that align when sequences are swapped over
8What is the scoring system that determines an optimal alignment?
- A+2 Match -1 Indel -2 Mismatch
- B+2 Mismatch -1 Match -2 Indel
- C+2 Match -1 Mismatch -2 Indel
9Needleman and Wunsch algorithms find the highest scoring path across a matrix
- ATrue
- BFalse
10Which is the light grey, and which is the dark grey?
- ALight- Remote homologues
Dark - Close homologues - BLight- Close homologues
Dark- Remote homologues
- ALight- Remote homologues
11PAM matrices used varies depending on the S.I
- ATrue
- BFalse
12PAM250 scoring is used for remote homologues
- ATrue
- BFalse
13In PAM250 scoring, scores are given based on what?
- AThe residue rarity
- BThe properties of the replacing residue- i.e. is one small hydrophobic residue replacing another
14What does BLAST stand for?
- ABasic Loci Alignment Search Tools
- BBasic Loci Alignment Sequencing Tools
- CBasic Local Alignment Search Tools
15What is different about BLAST techniques?
- AThe compare residue 'words' instead of single residues/bases
- BThey work in areas of less than 50bp long
- CThey cover the whole genome very rapdily
16A 'word' is 3bp or 11 aa long
- ATrue
- BFalse
17Once the words have been found in the sequence, they are compared to the database- why?
- ATo find exact matches
- BTo find evolutionary relationships
- CTo detect how common the words are
18An E value is expectation, not probability
- ATrue
- BFalse
19What is the range and significance for the E value?
Smaller values are more likely- A0-10
- B1-2
- C0-1
- D0.5
- E5
- F0.005
20The E value is the probability of getting a result by change in a database of this size
- ATrue
- BFalse
21What is the difference between P and E values
- ABoth are values for 'What is the probability of getting this result by chance alone?', but P accounts for database size
- BBoth are values for 'What is the probability of getting this result by chance alone?', E accounts for database size
22In P values, <0.05 is significant
- ATrue
- BFalse
23P value relies on a normal distribution
- ATrue
- BFalse
24What are the limits of P?
- A0-0.1
- B0-1
- C0-10
25An E of 4 is equal to - in a database of this size, I could get 4 matches by chance alone
- ATrue
- BFalse
Information
- Description
- Year 2 Quiz on Data Analysis, created by gina_evans0312 on 28/12/2013.
- Author
- gina_evans0312
- Language
- English
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- 508
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