Quiz
REPRO/NEPHRO BLOCK: Week 4 - More Kidneys
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Questions in this quiz (37)
1What is the correct order of blood vessels in the kidney?
- ARenal artery
Segmental arteries
Lobar arteries
Interlobar arteries
Arcuate arteries
Cortical radiate arteries
Afferent arterioles
Glomerulus - BRenal artery
Segmental arteries
Lobar arteries
Interlobar arteries
Cortical radiate arteries
Arcuate arteries
Afferent arterioles
Glomerulus - CRenal artery
Lobar arteries
Interlobar arteries
Segmental arteries
Cortical radiate arteries
Arcuate arteries
Afferent arterioles
Glomerulus - DRenal artery
Interlobar arteries
Lobar arteries
Arcuate arteries
Cortical radiate arteries
Segmental arteries
Afferent arterioles
Glomerulus
- ARenal artery
2What is the correct order of veins in the kidney?
- AGlomerulus
Efferent arterioles
Cortical radiate veins
Arcuate veins
Interlobar veins
Lobar veins
Segmental veins
Renal vein - BGlomerulus
Efferent arterioles
Arcuate veins
Cortical radiate veins
Interlobar veins
Lobar veins
Segmental veins
Renal vein - CGlomerulus
Efferent arterioles
Segmental veins
Lobar veins
Interlobar veins
Arcuate veins
Cortical radiate veins
Renal vein - DGlomerulus
Efferent arterioles
Cortical radiate veins
Arcuate veins
Lobar veins
Interlobar veins
Segmental veins
Renal vein
- AGlomerulus
3What is the lymphatic drainage of the kidneys?
- APara-aortic/lumbar lymph nodes
- BDeep inguinal lymph nodes
- CSuperficial inguinal lymph nodes
- DGroin lymph nodes
4Describe the process of bicarbonate reabsorption.
1. Bicarbonate is filtered by the glomerulus
---Inside the tubule it associates with [blank_start]H+[blank_end] to form [blank_start]carbonic acid[blank_end]
2. [blank_start]Carbonic anhydrase[blank_end] catalyses the [blank_start]dissociation[blank_end] of carbonic acid into [blank_start]H2O and CO2[blank_end]
---These can then be [blank_start]absorbed[blank_end] into the tubular cells
3. Inside the cell, [blank_start]carbonic anhydrase[blank_end] catalyses the reaction between H2O and CO2 to form [blank_start]carbonic acid[blank_end] again
4. The carbonic acid then [blank_start]dissociates[blank_end] into [blank_start]H+ and bicarbonate[blank_end] again
5. [blank_start]Selective permeability[blank_end] ensures that the ions are transported in the right directions:
---H+ is [blank_start]secreted back into the lumen[blank_end], as H+ channels are only found on the [blank_start]luminal[blank_end] side
---Bicarbonate is [blank_start]absorbed into the capillaries[blank_end], as bicarbonate channels are only found on the [blank_start]basolateral[blank_end] side- AH+
- Bcarbonic acid
- CCarbonic anhydrase
- Ddissociation
- EH2O and CO2
- Fabsorbed
- Gcarbonic anhydrase
- Hcarbonic acid
- Idissociates
- JH+ and bicarbonate
- KSelective permeability
- Lsecreted back into the lumen
- Mluminal
- Nabsorbed into the capillaries
- Obasolateral
5Describe the process of H+ excretion via titration with phosphate.
1. [blank_start]H2O and CO2[blank_end] react to form [blank_start]carbonic acid[blank_end] inside tubular cells, catalysed by [blank_start]carbonic anhydrase[blank_end]
---NOTE: the H2O and CO2 is [blank_start]new[blank_end], i.e. produced inside the cell and not reabsorbed from the filtrate
2. Carbonic acid dissociates to form [blank_start]H+ and a new bicarbonate ion[blank_end]
3. [blank_start]Bicarbonate[blank_end] is absorbed into the capillary from the [blank_start]basolateral[blank_end] side (via selective permeability)
4. [blank_start]H+[blank_end] is secreted back into the [blank_start]lumen[blank_end] (via selective permeability)
5. Some H+ associates with [blank_start]phosphate ions[blank_end] to form [blank_start]H2PO4[blank_end]
---This is then excreted in the urine- AH2O and CO2
- Bcarbonic acid
- Ccarbonic anhydrase
- Dnew
- EH+ and a new bicarbonate ion
- FBicarbonate
- Gbasolateral
- HH+
- Ilumen
- Jphosphate ions
- KH2PO4
6How much H+ is excreted via titration with phosphate per day?
- A40 mmol/day
- B50 mmol/day
- C60 mmol/day
- D70 mmol/day
7Describe the excretion of H+ via titration with ammonia.
1. [blank_start]Ammonia[blank_end] is produced in the [blank_start]PCT[blank_end]:
---[blank_start]Glutamine[blank_end] is reabsorbed from the filtrate
---Inside the tubular cell, [blank_start]glutaminase[blank_end] catalyses the breakdown of glutamine into [blank_start]NH4+ and bicarbonate[blank_end]
---[blank_start]Bicarbonate[blank_end] is reabsorbed into the capillary
---[blank_start]NH4+[blank_end] is secreted into the lumen
---NH4+ is converted to [blank_start]NH3[blank_end]
2. [blank_start]H2O and CO2[blank_end] react to form carbonic acid inside tubular cells, catalysed by [blank_start]carbonic anhydrase[blank_end]
---NOTE: the H2O and CO2 is new, i.e. produced inside the cell and not reabsorbed from the filtrate
3. Carbonic acid dissociates to form [blank_start]H+ and a new bicarbonate ion[blank_end]
4. [blank_start]Bicarbonate[blank_end] is absorbed into the capillary from the [blank_start]basolateral[blank_end] side (via selective permeability)
5. [blank_start]H+[blank_end] is secreted back into the [blank_start]lumen[blank_end] (via selective permeability)
6. Some H+ associates with [blank_start]NH3[blank_end] to form [blank_start]NH4+[blank_end]
7.NH4+ is then excreted in the urine- AAmmonia
- BPCT
- CGlutamine
- Dglutaminase
- ENH4+ and bicarbonate
- FBicarbonate
- GNH4+
- HNH3
- IH2O and CO2
- Jcarbonic anhydrase
- KH+ and a new bicarbonate ion
- LBicarbonate
- Mbasolateral
- NH+
- Olumen
- PNH3
- QNH4+
8How much H+ is excreted per day via titration with ammonia?
- A10-50 mmol/day
- B50-100 mmol/day
- C70-100 mmol/day
- D80-130 mmol/day
9How is the amount of H+ excretion in the urine increased when there are high levels of H+ in the blood?
- AUpregulation of glutaminase, leading to increased H+ excretion via titration with ammonia
- BIncreased phosphate excretion, leading to more phosphate in the tubules and increased H+ excretion via titration with phosphate
- CIncreased bicarbonate production in the tubular cells, leading to increased buffering in the blood to decrease H+ levels
- DDown-regulation of H2O and CO2 transport into tubular cells, leading to increased H+ excretion in carbonic acid
10What is the function of the mesangial cells in the juxtaglomerular apparatus?
- AUnknown
- BUnclear: possibly erythropoietin or smooth muscle-like functions
- CConstriction of the efferent arteriole to maintain GFR
- DVasodilation of the afferent arteriole to maintain GFR
11What is the function of juxtaglomerular cells?
- ASecretion of renin
- BSecretion of adenosine
- CDetection of tubular flow
- DVasodilation of the afferent arteriole to maintain GFR
12What is the function of the macula densa?
- ADetect tubular flow
- BAdenosine secretion
- CRenin secretion
- DVasodilation of the afferent artiole to maintain GFR
13How big are the ureters?
- ALength: 25-30 cm
Diameter: 3-4 mm - BLength: 30-35 cm
Diameter: 4-5 mm - CLength: 20-25 cm
Diameter: 2-3 mm - DLength: 35-40 cm
Diameter: 3-4 mm
- ALength: 25-30 cm
14Where are kidney stones most likely to get stuck?
- AUteropelvic junction
- BCrossing over the common iliac arteries at the pelvic brim
- CWhere ureters enter the bladder
- DMedial aspect of the psoas major muscle
- EPoint at which it enters the retroperitoneum
15Which of the following can cause kidney stones?
- APrimary hyperparathyroidism
- BPrimary hypoparathyroidism
- CHypercalcaemia
- DHypocalcaemia
- EPrimary/secondary hyperoxaluria
- FPrimary/secondary hypooxaluria
- GRenal tubular acidosis
- HHypocitraturia
- IHypercitraturia
16What is the correct order for the proportions of different types of kidney stones, from most common to least common?
- ACalcium containing (calcium phosphate/oxalate)
Magnesium ammonium phosphate (Struvite)
Urate
Cysteine
Mixed - BMixed
Calcium containing (calcium phosphate/oxalate)
Magnesium ammonium phosphate (Struvite)
Urate
Cysteine - CMixed
Magnesium ammonium phosphate (Struvite)
Calcium containing (calcium phosphate/oxalate)
Cysteine
Urate - DMagnesium ammonium phosphate (Struvite)
Calcium containing (calcium phosphate/oxalate)
Mixed
Cysteine
Urate
- ACalcium containing (calcium phosphate/oxalate)
17What is the most common composition of kidney stones?
- ACalcium containing (calcium phosphate/oxalate)
- BUrate
- CCysteine
- DStruvite
- EMixed
18How thick should the kidney cortex be?
- A1-2 cm
- B2-3 cm
- C3-4 cm
- D4-5 cm
19How much of the filtrate is reabsorbed by kidneys?
- A99% (180 L/day)
- B95% (175 L/day)
- C90% (165 L/day)
- D80% (140 L/day)
20Why is osmolality used to measure electrolyte concentrations, not osmolarity?
- AOsmolality is temperature independent
- BOsmolality is easier to calculate
- COsmolality is a more reliable measurement
- DOsmolality is recognised internationally
21How long is the PCT?
- A14mm
- B10mm
- C16mm
- D18mm
- E12mm
22How is sodium reabsorbed in the PCT? NOTE: not the co-transporters, just sodium on its own!
- ANa+/H+ exchanger
- BNa+ channel
- CNa+/HCO3- exchanger
- DNa+/Cl- exchanger
23How long is the DCT?
- A1mm
- B2mm
- C3mm
- D4mm
24What proportion of total reabsorption happens in the DCT?
- A25%
- B5%
- C15%
- D30%
- E10%
25What proportion of total reabsorption happens in the thick ascending loop of Henle?
- A25%
- B20%
- C30%
- D35%
26Describe the action of aldosterone.
1. [blank_start]Aldosterone[blank_end] binds to the intracellular [blank_start]mineralocorticoid receptor[blank_end]
2. Aldosterone-receptor complex binds to [blank_start]nucleus[blank_end] and acts as a transcription factor, causing:
---[blank_start]Stimulation of Na+/K+ ATPase[blank_end]
---[blank_start]Increased expression of K+ channels[blank_end] (therefore more potassium [blank_start]excretion[blank_end])
---[blank_start]Increased expression of Na+ channels[blank_end] (therefore more sodium [blank_start]reabsorption[blank_end])- AAldosterone
- Bmineralocorticoid receptor
- Cnucleus
- DStimulation of Na+/K+ ATPase
- EIncreased expression of K+ channels
- Fexcretion
- GIncreased expression of Na+ channels
- Hreabsorption
27What proportion of creatinine is excreted via tubular secretion?
- A0.5%
- B5%
- C10%
- D20%
28What are the correct values of minimum and maximum urine osmolality?
- AMinimum osmolality: 50 mosm/Kg
Maximum osmolality: 1400 mosm/Kg - BMinimum osmolality: 100 mosm/Kg
Maximum osmolality: 2000 mosm/Kg - CMinimum osmolality: 60 mosm/Kg
Maximum osmolality: 1400 mosm/Kg - DMinimum osmolality: 50 mosm/Kg
Maximum osmolality: 1200 mosm/Kg
- AMinimum osmolality: 50 mosm/Kg
29How much waste is excreted in the urine per day?
- A600 mosmol/day
- B400 mosmol/day
- C800 mosmol/day
- D1000 mosmol/day
30What are the correct values for minimum and maximum daily urine output?
- AMinimum urine output: 0.4 L/day
Maximum urine output: 12 L/day - BMinimum urine output: 0.3 L/day
Maximum urine output: 14L/day - CMinimum urine output: 0.5 L/day
Maximum urine output: 12 L/day - DMinimum urine output: 0.6 L/day
Maximum urine output: 14 L/day
- AMinimum urine output: 0.4 L/day
31What can cause dysfunctional reabsorption in the PCT?
- AFanconi's syndrome
- BAcetzolamide
- CBartter's syndrome
- DGitelman's syndrome
- ELiddle's syndrome
- FLoop diuretics
- GThiazide diuretics
- HK-sparing diuretics
32What can cause defective absorption through NKCC2 channels?
- AFanconi's syndrome
- BAcetazolamide
- CBartter's syndrome
- DLoop diuretics
- EGitelman's syndrome
- FThiazide diuretics
- GLiddle's syndrome
- HK-sparing diuretics
33What can cause dysfunctional absorption through NCC channels?
- AFanconi's syndrome
- BAcetazolamide
- CBartter's syndrome
- DLoop diuretics
- EGitelman's syndrome
- FThiazide diuretics
- GLiddle's syndrome
- HK-sparing diuretics
34What can cause dysfunctional reabsorption through ENaC channels?
- AFanconi's syndrome
- BAcetazolamide
- CBartter's syndrome
- DLoop diuretics
- EGitelman's syndrome
- FThiazide diuretics
- GLiddle's syndrome
- HK-sparing diuretics
35What is the normal (healthy) range of urine output per day?
- A0.8-2 L/day
- B0.5-4 L/day
- C0.4-12 L/day
- D0.6-3 L/day
36What is used for the quantification of protein in urinalysis?
- ASpot urinalysis for protein levels
- BUrinary protein:creatinine ratio
- C24 hour urine collection and urinary protein levels
- DConsecutive spot urinalysis for protein levels
37What are the main causes of acute kidney injury or chronic kidney disease?
1. [blank_start]Ineffective blood supply[blank_end]
2. [blank_start]Glomerular disease[blank_end]
3. [blank_start]Tubulo-interstitial disease[blank_end]
4. [blank_start]Obstructive uropathy[blank_end]- AIneffective blood supply
- BGlomerular disease
- CTubulo-interstitial disease
- DObstructive uropathy
Information
- Description
- Kidney function and anatomy
- Author
- Melissa Denker
- Language
- English
- Views
- 31
- History
- Created on 5 Dec 2015 · updated on 14 Dec 2016
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