Flashcards
Urinary Systems and Electrolytes V
Cards in this deck (23)
- 1Function of CC multiplierConcentrate urine in LOH
- 2Initial concentration of CCMWalls of AL impermeable to water
Walls of DL permeable
Osmotic gradient - 3Single effect generationA.T./Diffusion of NaCl out of AL to ISF
Dilutes tubule fluid, conc.'s ISF
H2O from DL to hyperosmotic ISF
Diffusion of Na/Cl to DL - 4The single effectDif in OSP and [Nacl]
btw. ALF/DLF/ISF
H2O moves out of DL to ISF until = - 5How does OSP' change in nephronOSP' increases as depth into medulla increases
- 6What does length of LOH determine?OSP' size and conc. of urine
- 7What is the vasa recta?Specialised capillary of juxtamedullary nephron
- 8What is the function?Creates a hyperosmotic ISF to draw as much water out of nephron as possible
Especially during antidiuresis - 9Salt diffusion from VRDVR:
plasma ~300 mOsm
Encounters ^ osmotic ISF as it descends
Salt diffuses from ISF to plasma, ^ its conc
AVR:
Conc. blood flows towards cortex from papilla
loses salt to increasingly dilute medullary ISF - 10SummarySalt reabsorbed from LOH trapped+recycled within medulla by CC flow of blood in vasa recta
- 11Water reabsorption in VRDVR:
Dilute blood flow into medulla loses H2O to ^ conc. medullar ISF
AVR:
Conc. blood flow from tip of papilla towards cortex gains H2O from ^ dilute medullary ISF - 12SummaryWater tends to short circuit from DVR-> AVR
helps preserve conc. of medullary ISF - 13Diagram of urea movementah
- 14Where is [urea] highinterstitium of inner medulla
- 15Why does inner medulla have a steep osmotic '?Facilitate constant reabsorption of H2O from DL
This maintains a high conc. of tubular fluid in DCT/CD, concentrating urine - 16Urea UniportersExpressed in CD
facilitates diff of urea from intertubular -> ISF
Further ^ OSP of ISF of inner medulla
Further ^ H2O reabsorption - 17Hormonal control Vasopressin (ADH)Upregulates urea uniporter expression of UT-A1/UT-A3
- 18UT-A2Expressed in LOH, passes urea from ISF to intertubular fluid
- 19VasopressinProduced in hypothalamus
Released by pituitary gland
^ H2O permeability of DCT/CD
^ BP as more h2o reabsorped
Decreases blood plasma osmolarity - 20How does ADH do this?Upregulates translocation of AQP channels to apical PCM of DCT/CD cells
- 21What happens when dehydratedWhen dehydrated less H2O available to be reabsorbed, urine more conc., more ADH released to ^ H2O reabsorption
- 22ReninCreates Angiotensin I from angiotensin
Converted to Angiotensin II
Stimulates adrenal cortex to produce aldosterone
Aldosterone ^ Na+ reabsorption
Angiotensin II also stimulates General Systemic Vasoconstriction - 23Stimulators of renin secretionLow BP
Low Na+ in DCT, sensed by Maculla Densa
SNS
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- User has deleted their subject information Flashcards on Urinary Systems and Electrolytes V, created by Deleted user on 31/03/2018.
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- Created by J yadonknow · Mar 31, 2018
- Copied by J yadonknow · Mar 31, 2018
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