Flashcards
Week 4: Liver and Bile
Cards in this deck (47)
- 1what is bilirubin derived from?myeoglobin, hemoglobin, destroyed RBC's, hemolysis
- 2How can drugs cause jaundice?causes hemolysis, causes bile stasis, competing with bilirubin for albumin, direct hepatic effect on toxic cells
- 3jendrassik Grofmethod for bilirubin, uses diazotized sulfanilic acid
- 4evelyn malloymeasures unconjugated bilirubin, dependent upon addition of methanol
- 5serum bilirubin methodsbilirubinometer,Jandrassik Grof, bilirubin oxidase
- 6Liver failureincreased PTA, bile NH3 and decreased albumin
- 7functions of liver-synthesis of cholesterol and bile acids, storage of vitamin A,
- 8how are liver fxns assessedALT and AST
- 9potentially toxic byproduct that is detoxified by the liverNH3
- 10urobilinbreakdown product of bilirubin metabolism produced in colon from the oxidation of urobiligen by microorganisms
- 11jaundiceyellow pigmentation of skin
- 12kernictiousabnormal accumulation of bile in the brain
- 13bilirubin metabolismRBC disenegrate, Hmg released and converted to pigment bilirubin by the spleen
- 14direct bilirubinconjugated in the liver, attached to glucoronic acid, excreted in urine of jaundice patient
- 15biliary destructionincreased total bilirubin, hemolytic jaundice,criggler najjar syndrome,
- 16hemolytic jaundice typescirhosis,criggler najjar, hepatitis, increased unconjugated bilirubin serum
- 17criggler najjardefficiency of an enzyme needed to conjugate bilirubin
- 18dubin johnsonexcessive conjugated bilirubin in urine
- 19cirrhosisalcoholism
- 20complete obstrucion of bile duct characterized byneg urobilogen in urine, neg fecal urobilogin in urine, excretion of pale colored stool
- 21major compund in non protein nitrogenurea
- 22how does nh3 keptbetween limits to maintain acid base balancesynthesis of urea from nh3
- 23disorders associated w increased blood nh3reyes syndrome, renal failure, chronic liver failure
- 24serum creatinine v GFRserum creatinine increases, GFR decreases
- 25BUN/ creatinine ratio and whats associated w increased BUN1:20, kidney failure, heart failure, dehydration and high protein
- 26process of creatininecreatine is precursor of creatinine
- 27Bartholaturea test blue green complex
- 28gaffe rxncolorimetric test for creatinine, alpaline conditions
- 29creatinine clearance testUxV/P, p =serum creatinine, used to assess GFR
- 30if urine is not fresh and requiring a creatinine level what must be donepH adjusted to 7
- 31why is creatinine a good substance for a claearnce test ?blood levels are stable
- 32creatine processfiltered by glomeruli, not reabsorbed by tubule, only secreted by tubules when plasma levels become elevated
- 33tests increased in renal failureK,mg,phos,urea,creatinine,uric acid, decreased are Ca and erythropoietin
- 34goutincrease in uric acid
- 35why do pple in chemo get gout sometimes?chemo increases uric acid
- 36end product of protein metabolismurea
- 37proximal tubule fxn-reabsorbs 80% of salt and H20
- 38relationship between serum creatinine and GFRinverse
- 39normal renal plasma flow600ml/min
- 40what happens to the BUN/creatinine ratio in prerenal azotemia?increased BUN/creatinine, (BUN should be higher)
- 41Proximal tubulereturns substances back to blood and secrete products of kidney metabolism,
- 42Proximal tubulereturns substances back to blood and secrete products of kidney metabolism,
- 43loop of henlereabsorbs H20, Na + Cl
- 44how to estimate Buncreatinine age race gender
- 45best accurate test for GFRcreatinine=Unpaired renal function
- 46dialysismethod for seperating macromolecules from solvent
- 47urea:urea nitrogen ratio2.14:1.0
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- Chemistry Rotation Flashcards on Week 4: Liver and Bile, created by Stacym09 on 10/10/2013.
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- Stacym09 · Oct 2013
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- Feb 19, 2016
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