Flashcards
PHOL1001
Cards in this deck (8)
- 1What are the criteria for a neurotransmitter (NT)?- presence
-stored in vesicles
-release
-effect
-termination of effect - 2What are the characteristics of transmitters in CNS?-always agonists
-can produce fast or slow events
-can excite or inhibit
-determined by receptors
-ion channel-fast-neurotransmission
- 2nd messengers-slow-neuromodulation - 3What are the characteristics of receptors?-determine the effects of transmitters and drugs
-excitatory or inhibitory - never both
-fast (msecs) or slow (sec to min) effects
-subtypes- can result in mixed effects - 4What is the role of pre-synaptic receptors?Pre-synaptic receptors alter NT release
(WHERE THEY CONTROL TRANSMITTER RELEASE) - 5What is the role of post-synaptic receptors?Post-synaptic receptors alter activity
(CONTROLLING NEURONAL FIRING) - 6What are the main types of neurotransmitters and their effects?*glutamate: major excitatory transmitter
*GABA: major INHIBITORY transmitter
-Acetylcholine: mixed effects
-Noradrenaline: mixed effects
-5HT: mixed effects
-Dopamine: mixed effects
> peptides- substance P (excitatory)
-opioids (inhibitory)
> nitric oxide: excitatory
> adenosine: inhibitory - 7What are the features of glutamate?* major excitatory transmitter in CNS
* most neurones respond to glutamate
* often found in long pathways
* point to point transmission
* can cause long term changes - 8Which four receptors act glutamate on?1. AMPA postsynaptic receptor (ionotropic)
2. NMDA postsynaptic receptor (ionotropic)
3. fast presynaptic excitatory KAINATE receptor
4. slow METABOTROPIC receptors (G-proteins)
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- Flashcards on PHOL1001, created by Margaret-Estefani Conde Paredes on 25/02/2017.
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- Margaret-Estefani Conde Paredes
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