Flashcards
129 - Endotoxins
Cards in this deck (33)
- 1—Endotoxin
(lipid A component) - 2—Macrophage activation (TLR4)
- 3—Complement activation
- 4—Tissue factor activation
- 5—IL-1, IL-6
- 6—TNF-α
- 7—Nitric oxide
- 8—C3a
- 9—C5a
- 10—Coagulation cascade
- 11—Fever
- 12—Fever and Hypotension
- 13—Hypotension
- 14—Histamine release:
Hypotension and edema
- 15—Neutrophil chemotaxis
- 16—DIC
- 17—
- 18—
- 19—
- 20—
- 21—
- 22Mnemonic Device To Remember ENDOTOXINS What is E in ENDOTOXINS?Edema
- 23Mnemonic Device To Remember ENDOTOXINS What is the first N in ENDOTOXINS? What is the second?Nitric oxide
Neutrophil chemotaxis - 24Mnemonic Device To Remember ENDOTOXINS What is the D in ENDOTOXINS?DIC/Death
- 25Mnemonic Device To Remember ENDOTOXINS What is the first O in ENDOTOXINS? What is the second?Outer membrane
O-antigen + core polysaccharide + lipid A - 26Mnemonic Device To Remember ENDOTOXINS What is the T in ENDOTOXINS?TNF-α
- 27Mnemonic Device To Remember ENDOTOXINS What is the X in ENDOTOXINS?eXtremely heat stable
- 28Mnemonic Device To Remember ENDOTOXINS What is the I in ENDOTOXINS?IL-1 and IL-6
- 29Mnemonic Device To Remember ENDOTOXINS What is the S in ENDOTOXINS?Shock
- 30Endotoxins Where is LPS found? In what?LPS found in outer membrane of gram ⊝
bacteria (both cocci and rods). - 31Endotoxins Composed of what?Composed of
O antigen + core polysaccharide + lipid A (the toxic component). - 32Endotoxins How are they released?Released upon cell lysis or by living cells by
blebs detaching from outer surface membrane (vs exotoxin, which is actively secreted). - 33Endotoxins Three main effects?Three main effects: macrophage activation
(TLR4), complement activation, and tissue
factor activation.
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- User has deleted their subject information Flashcards on 129 - Endotoxins, created by Deleted user on 15/05/2017.
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- Deleted user · May 2017
- Updated
- May 15, 2017
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- Created by Victoria Wright · May 15, 2017
- Copied by Victoria Wright · May 15, 2017
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