Pharmacokinetics notes
22 notes by 17 users
This GoConqr page gathers over 10 pharmacokinetics notes from more than 10 users, covering routes of administration, absorption, drug interactions and elimination. The collection is mainly at university level, for university students reviewing these topics and teachers looking for study material. Choose a note to start.
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- Pharmacokinetic and Pharmacodynamic Relationships13
- Routes of Drug Administration40
- Drug Absorption and Distribution55
- Drug Metabolism55
- Drug Elimination and Excretion5
- Drug Clearance and Half-Life14
- Pharmacokinetic Models and Calculations8
- Drug Interactions12
- Variability in Drug Response14
- Drug Dosing and Therapeutic Monitoring17
Notes
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Clinical Sciences 2 Week one review activities Review: PharmacokineticsThere are four pharmacokinetic processes depicted in the diagram. These determine how much drug reaches the site of action. Provide a brief definition of each process and ways a drug could move...
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Routes of administration Physical routes of administration Absorption = passage drug from site of administration into blood plasma Barriers to absorption may limit drug bioavailability @ target organs i) Epithelial Passive t...
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Introduction to Pharmacokinetics & movement of drug molecules What is pharmacokinetics? "movement of a drug & the processes affecting it" Time taken for drug to get into (A), around (D) & out (M & E) of the body Absorption Distribution Metabolism Excretion "wha...
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PK/PD Drug Interactions - created from Mind Map Pharmacokinetics= what the body does to the drug Pharmacodynamics= what drug dose to body Metabolism:ADMEWhat the drug does to the body Includes Absorption
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drug interactions Drug interactions Therapeutic index of an interacting drug cyclosporine – an immunosuppressant widely used to prevent organ transplant rejection, digoxin – a sodium ⁄ potassium ATPase pump inhibitor which was among th...
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Untitled ADME – Pharmacokinetics · The study of the time course of drug concentrations in the body · Provides practitioners with a useful tool to design optimally beneficial drug dosage schedules for each individual patient · ...
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Outline Chapter 3 Physiochemical and Biopharmaceutical Properties of Drug substances and Pharmacokinetics Gastrointestinal PhysiologyBiologic membraneMechanisms of Drug Absorption Passive Diffusion Carrier-Mediated or Active ...
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Oral Route of Drug Administration Oral Route Two general absorption mechanisms: Passive Diffusion: process is driven by concentration gradient across a cellular membrane from region of high concentration to that of a low concentration. Dependent on li...
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Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293077/Abstract BACKGROUND: High dose oral thiamine may have a role in treating diabetes, he...
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Untitled Drug interactions Therapeutic index of an interacting drug cyclosporine – an immunosuppressant widely used to prevent organ transplant rejection, digoxin – a sodium ⁄ potassium ATPase pump inhibitor which was among th...
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Vancomycin Dosing
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Pharmacology: Exam 1 1: Routes of Administration - KEY CONCEPTS What are the 3 main categories of Routes of Administration? Enteral: Advantages Disadvantages Examples of oral, sublingual, and rectal routes
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Principles of Drug Action Drug Administration Dosage and Routes: May determine amount of drug reaching receptors and its efficiency, toxicity and theraputic outcome Several routes and dosing intervals mau be recommended Pharmokinetic processes...
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Absorption - created from Mind Map physiological factors formulation factors physical-chemical factors
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Drugs - created from Mind Map Pharmacologystudy of how drugs affect the NS and behaviour Psychoactive drugssubstance that acts to alter mood, thought, or behaviour and is used to manage neuropsychological illness Administration Oral Inhaled absorb...
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Definitions Lecture 1 Paracelsus (1493–1541) Poison is in everything Is defined as what the body does to the drug (ADME processes) ADME processes occur simultaneously Significance of PK Dose and Rate Individualiz...
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Sources of pharmacokinetic variation Sources of variability i) Internal & external Internal factors
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Drug metabolism & elimination Drug metabolism i) General features ii) Sites of metabolism
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Extra notes: Biopharmaceutical Buccal, respiratory, rectal, intramuscular or subcutaneous routes of drug administration, transport the drug from the absorbing tissue into circulating blood supply. Intravenous route is the most direct route and abso...
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Formulas
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Drug concentration in systemic circulation - created from Mind Map Clinical response Drug in tissues of distributionDistribution Drug metabolizedElimination
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AMDE - created from Mind Map Absorption Distribution Metabolism
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About pharmacokinetics notes
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Start with Clinical Sciences 2 Week one review activities if you want a structured review. It asks for definitions of the processes that determine how much drug reaches its site of action. You can use those prompts to organise your own notes before reading further.
For a focused topic, Routes of administration covers ways drugs are given, while Drug metabolism & elimination looks at metabolism, elimination and clearance. The note on absorption brings together factors affecting movement across membranes.
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Read a section, close the note and write down the main points you remember. Then return to the text to check what you missed. You can compare those points with Sources of pharmacokinetic variation, which lists internal and external factors.
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Which note is a useful starting point?
Clinical Sciences 2 Week one review activities is a useful starting point for reviewing the processes that determine how much drug reaches its site of action. Its prompts ask for a brief definition of each process, giving you a way to organise your reading.
What topics do the notes cover?
The notes cover routes of administration, absorption, drug interactions, metabolism and elimination. Sources of pharmacokinetic variation also lists factors that can affect variability. You can choose a focused note for a particular topic or begin with the review activities for a broader starting point.
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Yes. Every note listed here is free to open and study without an account. The resources were made by GoConqr users. A free account also lets you save quiz scores and make your own quizzes, mind maps, flashcards and notes.