Clinical Immunology Final MCQs- 4th Year- PMU

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Clinical Immunology Final MCQs- 4th Year- PMU
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Resumen del Recurso

Pregunta 1

Pregunta
Which of the following methods is suitable for detectin of serum globulins?
Respuesta
  • Nephelometry
  • Radial immnodiffusion by manchini
  • Turbidimetry
  • NBT-test
  • The mantoux test

Pregunta 2

Pregunta
Type II allergic reations are realized by
Respuesta
  • anaphylaxis
  • complement-mediated cytolysis
  • immune complexes
  • infectious immunity

Pregunta 3

Pregunta
Monoclonal antibodies are
Respuesta
  • pure population of immunoglobulins with same structure ant antigen specifity
  • albumins that are coded from other group of genes
  • mixed population of immunoglobulins with same structure, but different antigen specifity
  • substrate causing expression of immunoglobulins from other class in B-cells

Pregunta 4

Pregunta
Which immunological method is not proper for detecting of specific IgE
Respuesta
  • Immuno-enzyme(ELİSA, immuno-blot technique)
  • Classical ones(agglutination, precuipitation)
  • Floucytometry
  • Chemilluminescence

Pregunta 5

Pregunta
Low levels of IgA are found in case of
Respuesta
  • allergic reaction
  • chronic granulamatosis disease
  • selective IgA deficit
  • macro-globulinemia

Pregunta 6

Pregunta
Auto immune disease due to antibodies could be a result of (point the wrong answer)
Respuesta
  • forming of antigen-antibody complexes
  • antibodies that blockade cell receptor
  • antibody-depended cell-mediated cytotocicitty(ADCC)
  • cell-mediated reaction

Pregunta 7

Pregunta
The name of resident macrophages in liver is
Respuesta
  • ostephages
  • lagerhance cells
  • kupfer cells
  • microglial

Pregunta 8

Pregunta
EBV can cause
Respuesta
  • Hepatoma
  • Nasopharyngeal carcinoma
  • Burkit lymphoma
  • Adenocaqrcinoma pulmonis

Pregunta 9

Pregunta
Which of the following indicators is the most important in case of detecting of immune status in AIDS
Respuesta
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The bence-jones protein

Pregunta 10

Pregunta
System lupus erythematosus
Respuesta
  • is caused by mutations in ds-DNA
  • is revealed with many symptoms and affects many organs
  • is an example of T-cell mediated disease
  • is a result of generating of immune complexes

Pregunta 11

Pregunta
The opsonisation is a process of
Respuesta
  • Ingestion and destruction of an antigen from phagocyte
  • Of covering of antigen with antibodies in purpose to ease phagocytosis
  • Of covering of antigen with complement in purpose to ease phagoytosis
  • Obtaining of monoclonal antibodies

Pregunta 12

Pregunta
Connect with arrows allergic diseases with relevant types allergic reactions: Type [blank_start]3[blank_end] - serum-disease Type [blank_start]4[blank_end] - contact dermatitis Type [blank_start]1[blank_end] - anaphylaxis Type [blank_start]2[blank_end]- hemolytic disease of newborn
Respuesta
  • 3
  • 1
  • 2
  • 4
  • 4
  • 1
  • 2
  • 3
  • 1
  • 2
  • 3
  • 4
  • 2
  • 1
  • 3
  • 4

Pregunta 13

Pregunta
The mature B-lymphocytes expresses onto their surface
Respuesta
  • IgM and IgD
  • IgM and IgA
  • IgD and IgE
  • IgG and IgD

Pregunta 14

Pregunta
The lymphocyte infiltration of thyroidea is typical for
Respuesta
  • The hashimoto thyroitidis
  • Euthyroid struma
  • Hemolytic anemia
  • Tuberculosis

Pregunta 15

Pregunta
The electrophoresis is
Respuesta
  • radial immunodiffusion in gel
  • separation of molecules in electric field
  • complement fixation reaction
  • electroimmunodiffusion

Pregunta 16

Pregunta
I type allergic reactions are
Respuesta
  • Immunocomplex
  • Cytotoxic
  • IgE mediated
  • Cell mediated

Pregunta 17

Pregunta
Connect with arrows autoimmune diseases from the left side with relevant characteristics from the right side: wide with relevant characteristics a. Multiple sclerosis [blank_start]6[blank_end] b. SLE [blank_start]4[blank_end] c. Myasthenia gravis [blank_start]5[blank_end] d. Pernicious anemia [blank_start]1[blank_end] e. Hashimoto thyoiditis [blank_start]2[blank_end] f. Hemolytic anemia [blank_start]3[blank_end] 1. autoantibodies against parietal cells of stomach ans intrinsic factor and as a result of this doesn't absorb Vitamin B12 2. autoantibodies against thyroglobuline and thyroid peroxidase 3. antibodies against epitopes of red blood cells 4. antibodies against nucleus antigens 5. antibodies against acetylcholine 6. antibodies against morbidly antigens in liquor and serum, depressed reactions of delayed type hypersensitivity against measles antigens
Respuesta
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 4
  • 1
  • 2
  • 3
  • 5
  • 6
  • 5
  • 1
  • 2
  • 3
  • 4
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 2
  • 1
  • 3
  • 4
  • 5
  • 6
  • 3
  • 1
  • 2
  • 4
  • 5
  • 6

Pregunta 18

Pregunta
The monoclonal antibodies, connected with diphtheria toxin could be used for
Respuesta
  • tumour diagnosis
  • immunostimulation
  • immunosupperession
  • immunotherapy of tumors

Pregunta 19

Pregunta
The defensins are
Respuesta
  • growth factors
  • antimicrobial peptides in granules of neutrophils
  • cytokines-mediators for immune response

Pregunta 20

Pregunta
What is the mechanism of III type allergic reactions
Respuesta
  • anaphylaxis
  • complement-mediated cytolsis
  • immune complexes
  • infectious immunity

Pregunta 21

Pregunta
Which of the following tumour markers are connected with melanoma maligna?
Respuesta
  • CA-15-3
  • gp 120
  • S100B
  • MART-1Melan A

Pregunta 22

Pregunta
Immuno-scintigraphy uses monoclonal antibodies against tumour antigen connected with
Respuesta
  • FITC
  • Rhodamine
  • Iodine 131, technetium
  • Enzyme

Pregunta 23

Pregunta
INF-γ is produced by
Respuesta
  • Activated T lymphocytes
  • Fibroblasts
  • B-lymphocytes
  • Leucocytes

Pregunta 24

Pregunta
What kind of auto-antibodies we find in patients with insulin-depended sugar diabetes?
Respuesta
  • Nucleus
  • Thyroid microsomes
  • IgG molecules
  • Island cells of pancreas

Pregunta 25

Pregunta
Rejection of a transplantant due to pre-forming antibodies in recipient is defined as
Respuesta
  • Hyper acute rejection
  • Accelerated
  • Acute
  • Chronic

Pregunta 26

Pregunta
What of the following possesses the most expressed oncogenic potential
Respuesta
  • Influenza virus type A
  • Ebola virus
  • EBV
  • Polioviruses 1,2 ,3
  • HPV

Pregunta 27

Pregunta
Is the following correct? Active immunity is a nospecific and is an ancient form of defense and lower degree of effectiveness?
Respuesta
  • True
  • False

Pregunta 28

Pregunta
Type IV allergic reactions are realized by means of
Respuesta
  • anaphylaxis
  • complement-mediated cytolysis
  • immune reactions
  • infectious immunity

Pregunta 29

Pregunta
True hypersensitivity reactions start usually after
Respuesta
  • 15-30 minutes
  • 48 hours

Pregunta 30

Pregunta
Which of the following characteristics does not belong to the Burkit lymphoma?
Respuesta
  • T-cell neoplasma
  • Is a non-hodgkin lymphoma
  • Has a connections with EBV
  • Is a B-cell lymphoma

Pregunta 31

Pregunta
Antigen presenting cells are
Respuesta
  • Dendrite cells and macrophages
  • T-lymphocytes
  • B-lymphocytes
  • Polymorphy-nuclear cells

Pregunta 32

Pregunta
We could use the mantoux test in diagnosis of (point two diseases) a- [blank_start]Tuberculosis[blank_end] b- [blank_start]Leprosy[blank_end]
Respuesta
  • Tuberculosis
  • Leprosy

Pregunta 33

Pregunta
Which of the following factors belong to the innate immunity?
Respuesta
  • Phagocytosis
  • T-lymphocytes
  • Complement, mucin, a-and b inferferons
  • Antibodies
  • Skin, mucus, normal flora
  • B-lymphocytes

Pregunta 34

Pregunta
What we could use as a subsrrate for detection of antinuclear antibodies throguh IFA?
Respuesta
  • rat liver
  • rat kidney
  • rat stomach
  • hep2 cell line

Pregunta 35

Pregunta
Which of the pointed immunological parameters is most important for detection of multiple myleoma?
Respuesta
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Pregunta 36

Pregunta
The most popular techniques for detection of antinuclear antibodies are
Respuesta
  • Agglutination
  • Indirect immunofluorescence
  • Neutralization test
  • The complement fixation test
  • ELISA
  • Direct immunofluorescence

Pregunta 37

Pregunta
CD3 molecule is a marker for
Respuesta
  • NK cells
  • Macrophages
  • Immunocompetent T lymphocytes
  • Mature B-lymphocytes

Pregunta 38

Pregunta
The accelerated reaction for rejection of transplantant is revealed
Respuesta
  • Intra-operative or immediately after operation
  • 24-to 72 hours after transplantation
  • Till the third month
  • 3 month after the transplantation

Pregunta 39

Pregunta
which of the following immunological indexes ids the most important for patients with chronic granulomatous disease?
Respuesta
  • NBT test
  • Anti DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Pregunta 40

Pregunta
CEA is increased in case of
Respuesta
  • nasopharyngeal carcinoma
  • the Burkit lymphoma
  • gatro-intestinal tumors
  • smokers

Pregunta 41

Pregunta
Which of the following is connected with damage of humoral immunity?
Respuesta
  • Di-George sydrome
  • Agamaglobulinemia of Bruton
  • Chronic candidosis of skin and mucus
  • Angioedema hereditaria

Pregunta 42

Pregunta
How many are complement activating ways?
Respuesta
  • one
  • three
  • two
  • four

Pregunta 43

Pregunta
The complement activation occurs via three pathways which are: 1. [blank_start]Classical[blank_end] pathway 2. [blank_start]Alternative[blank_end] pathway 3. [blank_start]Lectin[blank_end] pathway
Respuesta
  • Classical
  • Alternative
  • Lectin

Pregunta 44

Pregunta
The “respiratory burst" is related to
Respuesta
  • Humoral immunity
  • Cellular immunity
  • Phagocytosis
  • NK-cells function

Pregunta 45

Pregunta
The immune competence of T-lymphocytes is acquired in
Respuesta
  • Thyroidea
  • Bone marrow
  • Thymus
  • MALT

Pregunta 46

Pregunta
What expresses the CD8 molecule?
Respuesta
  • Macrophages
  • Antigen presenting cells
  • Cytotoxic T-lymphocytes
  • T- suppressors

Pregunta 47

Pregunta
What is human cell receptor for human immunodeficiency virus (HIV)?
Respuesta
  • CD3 molecule
  • CD8 molecule
  • CD4 molecule
  • CD19 molecule

Pregunta 48

Pregunta
Point the WRONG answer: Gamma interteron is produced by:
Respuesta
  • Non-activated macrophages and mastocytes
  • Leucocytes and Fibroblasts
  • Activated macrophages and NK cell
  • Lymphocytes

Pregunta 49

Pregunta
The determination of functional activity of the complement might be done by
Respuesta
  • Immune histochemical methods
  • Reaction neutratisation
  • CH50 test
  • Micro haemagglutination

Pregunta 50

Pregunta
CD4 molecule is situated on the surface of the
Respuesta
  • Monocytes
  • T-helpers
  • Cytotoxic T-lymphocytes
  • Plasmocytes

Pregunta 51

Pregunta
The presence of the antigen together with the MHC-II class molecules is realized by
Respuesta
  • Dendrite cells and macrophages
  • Cytotoxic T-lymphocytes
  • B-lymphocytes
  • Plasmocytes

Pregunta 52

Pregunta
A B-cell can synthesise some different antibodies with different species of the antigen
Respuesta
  • True
  • False

Pregunta 53

Pregunta
After the antigen stimulus the mature B-lymphocytes are transformed into
Respuesta
  • cytotoxic cell
  • immunocompetent cell
  • plasmocyte

Pregunta 54

Pregunta
What tests are for evaluation of the phagocytic activity?
Respuesta
  • Flow cytometry of detection of oxidative burst
  • Serum levels of immunoglobulins
  • CD4/CD8 index
  • NBT test

Pregunta 55

Pregunta
Paraproteinemias are detected in
Respuesta
  • Multiple myeloma
  • Reiter's Syndrome
  • Waldenstrom macroglobulinemia
  • Chronic lymphoid leukemia
  • SLE

Pregunta 56

Pregunta
Last cells, incapable to divide are
Respuesta
  • Plasmocytes
  • Neutrophils
  • T-lymphocytes
  • B-Iymphocytes

Pregunta 57

Pregunta
What do the mature B-lymphocytes express on their surface?
Respuesta
  • lgM and IgD
  • IgD ant IgE
  • IgM and IgA
  • IgG and IgD

Pregunta 58

Pregunta
How do CD8 eliminate their targets?
Respuesta
  • after recognition of antigen, connected with MCH-I class molecule
  • after recognition of antigen connected with MCH-II class molecule
  • via activation of an alternative way of complement
  • due releasing of interferon
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