3953058
Descripción
Test por Phil Oklam, actualizado hace más de 1 año
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Creado por Phil Oklam
hace más de 8 años
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Pregunta 1
Pregunta
Where is the TATA box?
Respuesta
-
-31 to -26
-
-32 to -37
-
-2 to +4
-
+28 to +32
Pregunta 2
Pregunta
Where is Inr?
Respuesta
-
-2 to +4
-
-37 to -32
-
-31 to -26
-
+28 to +32
Pregunta 3
Pregunta
Where is DPE?
Respuesta
-
+28 to +32
-
-2 to +4
-
-37 to -32
-
-31 to -26
Pregunta 4
Pregunta
Where is BRE?
Respuesta
-
-37 to -32
-
-31 to -26
-
-2 to +4
-
+28 to +32
Pregunta 5
Pregunta
Which are true of CpG Islands?
Respuesta
-
rich in CG sequences
-
TXN occurs at a lower rate and at several start sites
-
C residues escape methylation
-
Methylation is associated with silencing of the gene
-
Extensively phosphorylated at CTD
-
Form a complex on TATA box to recruit RNA Pol II to the promoter
Pregunta 6
Pregunta
Which of the following are associated with RNA Pol II?
Respuesta
-
tRNA
-
snRNA
-
mRNA
-
miRNA
-
rRNA
Pregunta 7
Pregunta
Which RNA Polymerase is found in the nucleolus?
Respuesta
-
RNA Pol I
-
RNA Pol II
-
RNA Pol III
Pregunta 8
Pregunta
Which of the following is the correct sequence for the formation of PIC?
Respuesta
-
DABPolFEH
-
DBAPolFEH
-
DABPolEFH
-
DAPolEBFH
Pregunta 9
Pregunta
Which GTF interacts with RNA Pol II during formation of PIC?
Respuesta
-
TFIIB
-
TFIID
-
TFIIA
-
TFIIE
-
TFIIH
-
TFIIF
Pregunta 10
Pregunta
What happens to RNA Pol II as it transcribes along RNA?
Respuesta
-
Phosphorylated at CTD
-
Methylated at CTD
-
Acetylated at CTD
-
Phosphorylated at N terminal tail
-
Acetylatetd at N terminal tail
Pregunta 11
Pregunta
Which of the following are true of TFIIH?
Respuesta
-
It binds over Inr
-
It binds over TATA
-
It requires ATP to separate template strand
-
It requires NAD to separate template strand
-
It is released as RNA Pol II moves
-
It stays bound as RNA Pol II moves
-
Its CAK subunit contains kinase for phosphorylation
-
Its Core subunit contains kinase for phosphorylation
-
It contains helicases XPB and XPD
-
It contains helicases XPC and XPB
Pregunta 12
Pregunta
Which of the following is a trilobular structure containing TBP and TAFs?
Respuesta
-
TFIID
-
TFIIH
-
TFIIE
-
TFIIA
-
TFIIB
-
RNA Pol II
Pregunta 13
Pregunta
TBP directs assembly of PIC on the TATA complex and only requires TAFs to do so in a TATA-less promoter
Respuesta
- True
- False
Pregunta 14
Pregunta
Which of the following are UAS common sequence elements?
Respuesta
-
GC box
-
Octamer
-
CAAT box
-
HSE
-
SRE
-
BRE
-
DPE
Pregunta 15
Pregunta
What are leucine zippers, zinc fingers, homeodomains and helix loop helixes all examples of?
Respuesta
-
DNA binding domains
-
Activation domains
-
Enhancer elements
-
GTFs
Pregunta 16
Pregunta
Which of the following are true of Activation domains in activators?
Respuesta
-
They have a lack of sequence conservation
-
They are generally unstructured
-
They contain multiple short segments working together in an additive fashion
-
They can be gln rich, proline rich or acidic patches
Pregunta 17
Pregunta
How do activators work?
Respuesta
-
Promote binding of other activators
-
Stimulate complex assembly (Recruitment)
-
Release stalled RNA Pol II
-
Modulation of chromatin
Pregunta 18
Pregunta
Which of the following are true of Mediator?
Respuesta
-
22 polypeptide complex
-
Comprised of a head, middle and tail
-
Associates with RNA Pol through CTD
-
Enhances PIC formation
-
Forms a bridge between RNA Pol II and activators
Pregunta 19
Pregunta
Which of the following is not a core histone?
Respuesta
-
H1
-
H3
-
H4
-
H2A
-
H2B
Pregunta 20
Pregunta
N terminal tails of histones are highly acidic
Respuesta
- True
- False
Pregunta 21
Pregunta
What do nucleosomes consists of?
Respuesta
-
2 x H2A-H2B dimers
-
H2A-H2B tetramer
-
H1 linker histones
-
H3-H4 tetramer
-
2 x H3-H4 dimers
-
147 bp DNA wrapped around the octamer
-
471 bp DNA wrapped around the octamer
Pregunta 22
Pregunta
Mitotic chromosomes are condensed, interphase chromosomes occupy a distinct territory in the nucleus and are decondensed to about 100-400nm fibres
Respuesta
- True
- False
Pregunta 23
Pregunta
Which of the following switches off the Gal4 promoter?
Respuesta
-
Galactose
-
Glucose
Pregunta 24
Pregunta
Which of the following are methods of remodelling chromatin?
Respuesta
-
Histone variants
-
ATP dependent chromatin remodelling
-
Post translational modifications
Pregunta 25
Pregunta
Which histone does not express variants?
Respuesta
-
H4
-
H3
-
H1
-
H2A
-
H2B
Pregunta 26
Pregunta
Where do post translational modifications of histones occur?
Respuesta
-
N-terminal tail
-
Histone variants
-
C Terminal domain
-
DPD
-
TBP
Pregunta 27
Pregunta
The GNAT and MYST family are which enzymes?
Respuesta
-
HATs
-
HDACs
-
HKMTs
-
SWI/SNF ATPase
Pregunta 28
Pregunta
Histone methylation is readily reversible and has no affect on charge
Respuesta
- True
- False
Pregunta 29
Pregunta
Specific methylated lysines are recognised by specific proteins, which of the following are markers for repression?
Respuesta
-
H3 Lys 9
-
H3 Lys 27
-
H3 Lys 4
-
H3 Lys 36
Pregunta 30
Pregunta
Which of the following are SWI2/SNF2 ATPase subfamilies?
Respuesta
-
SWI2/SNF2
-
ISWI
-
CHD/Mi2
-
Ino80
Pregunta 31
Pregunta
What is the deletion of SWI/SNF associated with?
Respuesta
-
Tumours
-
Tumour suppression
Pregunta 32
Pregunta
Which class of HDACs is not zinc dependent?
Respuesta
-
Class III
-
Class I
-
Class II
-
Class IV
Pregunta 33
Pregunta
Regions of DNA that are hypoacetylated by HDACs are what?
Respuesta
-
Repressed
-
Activated
Pregunta 34
Pregunta
Which of the following is an example of an ATP dependent remodeller that commonly mediates repression?
Respuesta
-
NuRD
-
SWI/SNF
-
Ume3
-
Rpd3
-
Sin3
-
HP1
Pregunta 35
Pregunta
What is the name of the enzyme that methylates H3K9?
Respuesta
-
Suvar39
-
HP1
-
NuRD
-
Sin3
-
Ume6
Pregunta 36
Pregunta
Is Tsix or Xist on the antisense strand of DNA?
Respuesta
-
Tsix
-
Xist
Pregunta 37
Pregunta
What is the Role of NF-KB family of transcription factors?
Respuesta
-
Regulating inflammation, DNA damage, cell death, cell adhesion and proliferation.
-
The guardian of the genome.
Pregunta 38
Pregunta
NF-KB is pre-synthesised and retained within the cytoplasm in an active form bound to inhibitor protein IxB
Respuesta
- True
- False
Pregunta 39
Pregunta
Cellular [blank_start]stimulation[blank_end] > IkB phosphorylated > ubiquitination by E3 Ubiquitin ligase > degradation by 26S proteasome > NF-kB free to translocate to the nucleus.
Respuesta
-
stimulation
-
degradation
Pregunta 40
Pregunta
In diseased cells NF-kB control is lost (aberrantly nuclear)
Respuesta
- True
- False
Pregunta 41
Pregunta
Which of the following do all members of the mammalian NF-KB family contain?
Respuesta
-
Rel homology domains
-
Leucine zipper like domain
-
Non conserved transcription activation domains
-
PEST domains
-
ankyrin repeat motifs
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