Quiz
CMB2001 Quiz
This quiz has question types that open in the usual player.
Questions in this quiz (41)
1Where is the TATA box?
- A-31 to -26
- B-32 to -37
- C-2 to +4
- D+28 to +32
2Where is Inr?
- A-2 to +4
- B-37 to -32
- C-31 to -26
- D+28 to +32
3Where is DPE?
- A+28 to +32
- B-2 to +4
- C-37 to -32
- D-31 to -26
4Where is BRE?
- A-37 to -32
- B-31 to -26
- C-2 to +4
- D+28 to +32
5Which are true of CpG Islands?
- Arich in CG sequences
- BTXN occurs at a lower rate and at several start sites
- CC residues escape methylation
- DMethylation is associated with silencing of the gene
- EExtensively phosphorylated at CTD
- FForm a complex on TATA box to recruit RNA Pol II to the promoter
6Which of the following are associated with RNA Pol II?
- AtRNA
- BsnRNA
- CmRNA
- DmiRNA
- ErRNA
7Which RNA Polymerase is found in the nucleolus?
- ARNA Pol I
- BRNA Pol II
- CRNA Pol III
8Which of the following is the correct sequence for the formation of PIC?
- ADABPolFEH
- BDBAPolFEH
- CDABPolEFH
- DDAPolEBFH
9Which GTF interacts with RNA Pol II during formation of PIC?
- ATFIIB
- BTFIID
- CTFIIA
- DTFIIE
- ETFIIH
- FTFIIF
10What happens to RNA Pol II as it transcribes along RNA?
- APhosphorylated at CTD
- BMethylated at CTD
- CAcetylated at CTD
- DPhosphorylated at N terminal tail
- EAcetylatetd at N terminal tail
11Which of the following are true of TFIIH?
- AIt binds over Inr
- BIt binds over TATA
- CIt requires ATP to separate template strand
- DIt requires NAD to separate template strand
- EIt is released as RNA Pol II moves
- FIt stays bound as RNA Pol II moves
- GIts CAK subunit contains kinase for phosphorylation
- HIts Core subunit contains kinase for phosphorylation
- IIt contains helicases XPB and XPD
- JIt contains helicases XPC and XPB
12Which of the following is a trilobular structure containing TBP and TAFs?
- ATFIID
- BTFIIH
- CTFIIE
- DTFIIA
- ETFIIB
- FRNA Pol II
13TBP directs assembly of PIC on the TATA complex and only requires TAFs to do so in a TATA-less promoter
- ATrue
- BFalse
14Which of the following are UAS common sequence elements?
- AGC box
- BOctamer
- CCAAT box
- DHSE
- ESRE
- FBRE
- GDPE
15What are leucine zippers, zinc fingers, homeodomains and helix loop helixes all examples of?
- ADNA binding domains
- BActivation domains
- CEnhancer elements
- DGTFs
16Which of the following are true of Activation domains in activators?
- AThey have a lack of sequence conservation
- BThey are generally unstructured
- CThey contain multiple short segments working together in an additive fashion
- DThey can be gln rich, proline rich or acidic patches
17How do activators work?
- APromote binding of other activators
- BStimulate complex assembly (Recruitment)
- CRelease stalled RNA Pol II
- DModulation of chromatin
18Which of the following are true of Mediator?
- A22 polypeptide complex
- BComprised of a head, middle and tail
- CAssociates with RNA Pol through CTD
- DEnhances PIC formation
- EForms a bridge between RNA Pol II and activators
19Which of the following is not a core histone?
- AH1
- BH3
- CH4
- DH2A
- EH2B
20N terminal tails of histones are highly acidic
- ATrue
- BFalse
21What do nucleosomes consists of?
- A2 x H2A-H2B dimers
- BH2A-H2B tetramer
- CH1 linker histones
- DH3-H4 tetramer
- E2 x H3-H4 dimers
- F147 bp DNA wrapped around the octamer
- G471 bp DNA wrapped around the octamer
22Mitotic chromosomes are condensed, interphase chromosomes occupy a distinct territory in the nucleus and are decondensed to about 100-400nm fibres
- ATrue
- BFalse
23Which of the following switches off the Gal4 promoter?
- AGalactose
- BGlucose
24Which of the following are methods of remodelling chromatin?
- AHistone variants
- BATP dependent chromatin remodelling
- CPost translational modifications
25Which histone does not express variants?
- AH4
- BH3
- CH1
- DH2A
- EH2B
26Where do post translational modifications of histones occur?
- AN-terminal tail
- BHistone variants
- CC Terminal domain
- DDPD
- ETBP
27The GNAT and MYST family are which enzymes?
- AHATs
- BHDACs
- CHKMTs
- DSWI/SNF ATPase
28Histone methylation is readily reversible and has no affect on charge
- ATrue
- BFalse
29Specific methylated lysines are recognised by specific proteins, which of the following are markers for repression?
- AH3 Lys 9
- BH3 Lys 27
- CH3 Lys 4
- DH3 Lys 36
30Which of the following are SWI2/SNF2 ATPase subfamilies?
- ASWI2/SNF2
- BISWI
- CCHD/Mi2
- DIno80
31What is the deletion of SWI/SNF associated with?
- ATumours
- BTumour suppression
32Which class of HDACs is not zinc dependent?
- AClass III
- BClass I
- CClass II
- DClass IV
33Regions of DNA that are hypoacetylated by HDACs are what?
- ARepressed
- BActivated
34Which of the following is an example of an ATP dependent remodeller that commonly mediates repression?
- ANuRD
- BSWI/SNF
- CUme3
- DRpd3
- ESin3
- FHP1
35What is the name of the enzyme that methylates H3K9?
- ASuvar39
- BHP1
- CNuRD
- DSin3
- EUme6
36Is Tsix or Xist on the antisense strand of DNA?
- ATsix
- BXist
37What is the Role of NF-KB family of transcription factors?
- ARegulating inflammation, DNA damage, cell death, cell adhesion and proliferation.
- BThe guardian of the genome.
38NF-KB is pre-synthesised and retained within the cytoplasm in an active form bound to inhibitor protein IxB
- ATrue
- BFalse
39Cellular [blank_start]stimulation[blank_end] > IkB phosphorylated > ubiquitination by E3 Ubiquitin ligase > degradation by 26S proteasome > NF-kB free to translocate to the nucleus.
- Astimulation
- Bdegradation
40In diseased cells NF-kB control is lost (aberrantly nuclear)
- ATrue
- BFalse
41Which of the following do all members of the mammalian NF-KB family contain?
- ARel homology domains
- BLeucine zipper like domain
- CNon conserved transcription activation domains
- DPEST domains
- Eankyrin repeat motifs
Information
- Description
- lectures 1-4
- Author
- Phil Oklam
- Language
- English
- Views
- 165
- Tags
- Rating
- No ratings yet Rate this quiz