Test
Oncogene Classification
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Preguntas del test (62)
1Give an example of a Class 1 Onocgene- Growth Factors
- AErb-B
- BERK
- CSis
2What is the function of the sis protein?
- AForms a PDGF(Beta) chain
- BForms a IPGF(Beta) chain
- CForms a IGF1(Beta) chain
3Name the two ways a cell can access extra Growth factor
- AA virus produces extra growth factor as it replicates
- BA cell begins to make it's own growth factor through growth factor genes
- CA cell begins to steal growth factor from surrounding cells
4Name the Class 2 oncogene
- AGrowth Factor Receptors
- BGrowth Factors
- CIntracellular Transducers
5Name a Class 2 Oncogene
- AErb-B
- BSis
- CIGF1
- DTGFB
6How does Erb-b become oncogene?
- A....bind permanently to their ligand and so become constitutionally active
- B... no longer need their ligand to activate become constitutionally active
- C...form a constitutionally active dimer
- D...no longer needs to dimerise to activate
7What is erb-b?
- AFamily of tyrosine kinase receptors that bind to EGF
- BFamily of tyrosine kinase receptors that bind to TGFB
- CFamily of tyrosine kinase receptors that bind to IGF1
8Similarly, in 'neu' receptors, what replaces the Valine to make a constantly active receptor?
- AGlutamine
- BGlutamic Acid
- CGlutamate
9What is Herceptin?
- AA tyrosine kinase agonist?
- BA humanised monoclonal antibody
- CAn Erb-B agonist
10What does Herceptin bind to?
- AErb B
- BHER2
- CTyrosine Kinase
11Name the 3rd Class of Oncogenes
- AGrowth factors
- BTranscription factors
- CIntracellular transducers
12Which of the following is a class 3A oncogoene?
- AErb-B
- BSrc
- Cc-myc
13What determines the types of src tyrosine kinase present in the cell?
- AThe cell type
- BThe stage of the cell cycle
- CThe age of the cycle
14What is the role of Cellular Transducers
- ARelay information to the nucleus to regulate gene transcription
- BRelay information to the ribosomes to regulate protein synthesis
- CRelay information to the Golgi Complex to regulate cell receptor production
15What allows Src to stick to the cytoplasm
- AA modified lipid
- BA modified glycoprotein
- CA modified phospholipid
16Name the substance that anchors src to the membrane
- AMyristate
- BPalmatite
- CAcetylate
17What holds src kinase shut in its inactive form?
- AA phosphate on Tyr 527 in its inactive form & the SH2 domain
- BA phosphate on Tyr 527 in its inactive form & the SH3 domain
- CA phosphate on Tyr 537 in its inactive form & the SH2 domain
18Put the following domains of Src in order
A- Unique Domain
B- Sh2 Domain
C-Catalytic Domain
D- Regulatory Domain
E- SH3- AA-B-E-C-D
- BA-B-C-D-E
- CA-B-D-E-C
19What is the focus of an SH3 domain?
- AProtein- protein interaction
- BProtein- phosphotyrosine interaction
- CProtein-phosphoserine interactoin
20What sequence is favored by SH3 domains?
- AProline rich; Pro-X-X-Pro
- BHistadine rich; His-X-X-His
- CGycine rich; Gy-X-X-Gly
21What is required for Src to activate?
- AFor the protein to be at the membrane
- BFor the protein to be cytosolic
- CThe SH2 domain then releases the regulatory domain and binds to P-Tyrosine Kinase
22What happens to the regulatory domain once the SH2 domain has released it?
- AIt's dephosphorylated by a phosphatase at the membrane at Tyr 527
- BIt's phosphorylated by the tyrosine kinase at Tyr 527
- CNothing
23What tyrosine residue is phosphorylated by tyrosine kinase?
- A416 on the activation lip
- B417 on the activation lip
- C418 on the activation lip
24What is the most common oncogene form of src?
- ALoss of regulatory domain (last 19 amino acids) so it cannot be phosphorylated
- BLoss of SH2 domain so it cannot bind to regulatory domain when phosphorylated
- CModified lipid binds permanently to the membrane
25Ras is the name of a small family of what?
- AGTPase's
- BATPase's
- CUTPase's
26What process localyses Ras to the membrane?
- AAcetylation
- BMethylation
- CFarnesylation
27What is sos?
- AA GAP
- BA GEF
- CA GDI
28Where does GTP bind to ras?
- AAt the C and N terminus
- BIn the centre
29What is the purpose of the discrete domain of Ras
- ATo bind GTP
- BTo bind GDP
- CTo bind downstream molecules
30What are GDI's?
- AGuanine Nucleotide Disassociation Inhibitors
- BGuanine Nucleotide Dimerisation Inhibitors
- CGunanine Nucleotide Decamerisation Inhibitors
31What is the purpose of a GDI and how it controlled?
- ABy molecules recruited to the tyrosine receptor
- BBind to Ras and prevent activation
- CBind to Ras and prevent de-activation
32In which domains can a single mutation turn Ras into an oncogene?
- AL1
- BL2
- CL3
- DL4
- EL5
33What is the role of GRB2
- ABinds Ras to membrane
- BBinds Ras to TK receptor
- CBinds Ras to Raf
34How many SH2 domains does GRB2 have?
- A2- both in the middle
- B2- one on each end
- C1 in the middle
- D1 at the N terminus
- E1 at the C terminus
35What protein is used by Src to activate Ras?
- ASrk
- BSch
- CShc
36How does src phosphorylate the protein that activates Ras?
- ABinds to SH3 domain
- BBinds to SH2 domain
- CBinds to discrete domain
37Name the two proteins for which phosphorylated Shc has a very high affinity?
- ARas
- BSos
- CGRB2
- DGDI
38Name the 4th class of oncogenes
- AGrowth factors
- BCellular Transporters
- CGrowth Factor Receptors
- DTranscription factors
39Name a class 4 oncogene
- ASrc
- BRas
- CJun
40Name the part of c-jun that causes dimerisation
- ALeu Zipper
- BHis zipper
- CAla zipper
41Where is the unique sequence of c-jun and what is it's role?
- ANear the center
- BNear the c-terminus
- CNear the n-terminus
- DDefines family member
- EDetermines where in the DNA c-jun binds
42Put the domains of C-jun in the correct order A-Leu Zipper B- Delta Domain C-Transcription Domain D- Unique Domain E- DNA Binding Domain
- AD-B-C-E-A
- BD-E-A-B-C
- CC-A-D-B-E
43How does C-jun function
- AAs a homodimer
- BAs a heterodimer
- CAs both
44What is the first step of c-jun homodimer activation?
- ADephosphorylation by PKC
- BPhosphorylation by JNK (ERK parallel protein)
45What is the second step of c-jun homodimer activation?
- ADephosphorylation by PKB
- BPhosphorylation by JNK
46What part(s) of c-jun is lost to make it an oncogene?
- AUnique sequence
- BDelta Domain
- CLeu zipper
47Name a protein likely to form a heterodimer with c-jun
- AAFK
- BAFT
- CAFR
48What tends to be transcribed by the first c-jun heterodimer to form?
- Ac-jun
- BAFK
- CFos
49What is the second protein to heterodimerise with c-jun?
- AFos
- BFas
- CFis
50What is the name of the second heterodimer formed by c-jun?
- AAP1
- BAp2
- CAP
51What is required for Fos transcription?
- ATCF/AFK to be activated by ERK
- BAFK to be activated by ERK
- CTCF to be activated by ERK
52What sequences does AP1 bind to?
- ATGAC
- BGTAC
- CGGAC
53What is transcribed by AP1?
- ATranscription factors
- BRibosomal proteins
- CGrowth factors
54Is Cyclin D1 transcribed by Jun?
- AYes
- BNo
55What happens if the signal activating AP1 persists for 30 mins?
- AIt's activity is increased further by phosphorylation
- BIt's activity is increased further by methylation
- CBy Jnk/Erk
56What transcribes C-Myc?
- AAPI
- BFos
- Cc-Jun
57How long is the half life of C-myc?
- A5-10 mins
- B5-10 seconds
- C3-5 mins
58What does Myc bind to in order to interact with E-Box sequences?
- AMax
- BMad
- CMac
59Why is Ubiquitin ligase transcribed by c-myc?
- AHalts protein turnover & allows protein levels to build up
- BIncreases protein turnover so only new proteins are involved in the cell cycle
60In normal cells, which of the following is in excess, and why?
- AMax, so the dimer only forms when Myc levels are signaled to rise
- BMic, so the dimer only forms when Max levels are signalled to rise
61How are Max homodimers inhibitory?
- AThey block jun transcription sites
- BThey block jun expression promoters
- CThey block myc expression promoters
62What is different in tumor cells from normal cells (concerning myc/max levels)?
- AMyc levels are always higher than Max
- BMax levels are always higher than myc
Información
- Descripción
- Year 2 Test sobre Oncogene Classification, creado por gina_evans0312 el 02/12/2013.
- Autor
- gina_evans0312
- Idioma
- English
- Visitas
- 607
- Historial
- Creado el 2 dic 2013 · actualizado el 1 dic 2016
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- Valoración
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