440326
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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Pregunta 1
Pregunta
5% of the human genome is genes that add a phosphate to something using ATP (Kinases)
Respuesta
- True
- False
Pregunta 2
Pregunta
Which of the following residues can be phosphorylated by kinases?
Respuesta
-
Serine
-
Threonine
-
Tyrosine
-
Valine
-
Argenine
-
Glutamic Acid
Pregunta 3
Pregunta
How many different kinases are there (roughly)?
Respuesta
-
510
-
520
-
530
Pregunta 4
Pregunta
In kinases, DFG & RC motifs are highly conserved
Respuesta
- True
- False
Pregunta 5
Pregunta
Which domains are commonly found in kinase interacting proteins?
Respuesta
-
SH1
-
SH2
-
SH3
Pregunta 6
Pregunta
SH3 proteins mediate the assembly of proteins structures by binding to proline rich peptides in them
Respuesta
- True
- False
Pregunta 7
Pregunta
SH domains modulate protein interactions by recognizing and binding to specific proteins by identifying specific peptide sequences
Respuesta
- True
- False
Pregunta 8
Pregunta
What is the role of PH domains?
Respuesta
-
Binding the protein to the ER membrane
-
Binding the protein to the cell membrane
-
Binding the protein to nuclear membrane
Pregunta 9
Pregunta
Membranes form what?
Respuesta
-
Compartments & permeability barriers
-
Compartments & osmotic barriers
Pregunta 10
Pregunta
What mediate membrane functions?
Respuesta
-
Proteins
-
Glycolipids
-
Phospholipid concentration
Pregunta 11
Pregunta
Mitochondiral membranes contail the most proteins, plasma membranes contain the least (Out of Mitochondrial, Plasma and Myelin membranes)
Respuesta
- True
- False
Pregunta 12
Pregunta
Most integral membrane proteins span the membrane
Respuesta
- True
- False
Pregunta 13
Pregunta
Integral proteins interact extensively with what?
Respuesta
-
The hydrocarbon chains of lipids
-
The phosphate groups of phospholipids
-
The hydrocarbon tails of phospholipids
Pregunta 14
Pregunta
Peripheral proteins are bound to the membrane via the head groups of phospholipids
Respuesta
- True
- False
Pregunta 15
Pregunta
How do we tell how strongly a membrane protein is associated?
Respuesta
-
Try and disassociate it using detergent
-
Try and disassociate it using water
Pregunta 16
Pregunta
Baterial Rhodopsin uses heat to pump protons out of the membrane
Respuesta
- True
- False
Pregunta 17
Pregunta
How is the hydrophobic core formed in baterorhodopsin?
Respuesta
-
7 alpha helices
-
7 beta sheets
-
3 alpha helices, 4 beta sheets
Pregunta 18
Pregunta
In the case of the highly conserved 'Membrane Spanning Alpha Helix Structure', what must be on the outside?
Respuesta
-
Phospholipids
-
Non-polar aa
-
Polar aa
Pregunta 19
Pregunta
The membrane spanning alpha helix structure acts as what?
Respuesta
-
A scaffold for the active site
-
The active site
-
The channel for the active site to move through
Pregunta 20
Pregunta
Transmembrane helices can be predicted by a long string (or more) of hydrophobic amino acids in their aa sequence
Respuesta
- True
- False
Pregunta 21
Pregunta
What is used to estimate the free energy change of a residue on transfer of a residue to water (i.e. how much energy does it take to disassociate the aa from the protein)?
Respuesta
-
A polarity scale
-
An amino scale
-
A pH scale
Pregunta 22
Pregunta
An amino acid with high energy lies buried in a hydrophobic region i.e. the membrane
Respuesta
- True
- False
Pregunta 23
Pregunta
How large is the hydrocarbon core of the membrane?
Respuesta
-
30A
-
32A
-
34A
Pregunta 24
Pregunta
What is the name of the 20aa section of an integral protein that spans the membrane?
Respuesta
-
Pocket
-
Window
-
Scaffold
Pregunta 25
Pregunta
How is a Hydropathy plot formed?
Respuesta
-
The free energy change for each 20 aa segement plotted against the first aa in each segment
-
The free energy change for each 20 aa segement plotted against the last aa in each segment
-
The free energy change for each 30 aa segement plotted against the first aa in each segment
Pregunta 26
Pregunta
What is the point of a hydropathy plot?
Respuesta
-
To find which aa are in hydrophobic areas
-
To find the window of integral proteins
-
To find the window of peripheral proteins
Pregunta 27
Pregunta
The criterion level for a hydropathy plot is +68
Respuesta
- True
- False
Pregunta 28
Pregunta
What is Porin an example of?
Respuesta
-
Membrane spanning alpha helices
-
Membrane spanning beta sheets
-
Membrane spanning helix/beta sheet structure
Pregunta 29
Pregunta
What tends to be the features of membrane spanning beta sheet residues?
Respuesta
-
Hydrophobic
-
Hydrophillic
-
Alternating hydrophobic and hydrophilic
Pregunta 30
Pregunta
The polarity of the internal aa in a membrane spanning beta sheet depends on the size
Respuesta
- True
- False
Pregunta 31
Pregunta
Each sheet in the m.s beta sheet arrangement is hydrogen bonded to its neighbor in a parallel manner
Respuesta
- True
- False
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