454011
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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Pregunta 1
Pregunta
Which of the following are caused by hydrolysis?
Respuesta
-
Nicks
-
Abasic Sites
-
Cross Links
-
Ds Breaks
Pregunta 2
Pregunta
Which of the following are caused by Radical Oxygen Species?
Respuesta
-
Bulky alkylation damage
-
Abasic sites
-
ds breas
-
ss breaks
-
Nicks
Pregunta 3
Pregunta
What causes Alkylation Damage?
Respuesta
-
S-adenosyl methionine
-
Radical oxygen species
-
Interacts with 6th O on guanine
-
Interacts with 3rd O on guanine
Pregunta 4
Pregunta
Methylation of guanine results in unstable base pairing
Respuesta
- True
- False
Pregunta 5
Pregunta
Over two cycles of replication, a methylated C-G will be replaced with an?
Respuesta
-
A-T
-
C-C
-
G-T
Pregunta 6
Pregunta
What protein catalyses Direct Reversal of Guanine methylation?
Respuesta
-
Alkyl-Guanine Transferase
-
Adenosyl-Guanine Transferase
-
Adenyl-Guanine Transferase
Pregunta 7
Pregunta
The enzyme involved in direct reversal catalyses the transfer of CH3 to the enzyme, killing it
Respuesta
- True
- False
Pregunta 8
Pregunta
How does the Direct Reversal enzyme 'flip out' the damaged guanine?
Respuesta
-
A helix-helix motif
-
A helix-turn-helix motif
-
A sheet-turn-sheet motif
Pregunta 9
Pregunta
The enzyme for direct reversal is not specific and so works globally
Respuesta
- True
- False
Pregunta 10
Pregunta
What is the reading head of the Direct Reversal enzyme made of?
Respuesta
-
Ala & Gly
-
Ser & Val
-
Tyr & Ser
Pregunta 11
Pregunta
The enzyme binds to the major groove using an HTH motif
Respuesta
- True
- False
Pregunta 12
Pregunta
Which happens first in the CH3 transfer?
Respuesta
-
Lys pushes H onto Tyr
-
Lys pushes CH3 onto Tyr
-
Tyr pushes H onto Lys
Pregunta 13
Pregunta
The new H+ pushes e-....
Respuesta
-
Onto CH3
-
Onto O bound to CH3
-
Onto Lys bound to CH3
Pregunta 14
Pregunta
The e- added to the O pushes the CH3 onto the Lysine
Respuesta
- True
- False
Pregunta 15
Pregunta
Which of the following recognises the widowed G and fills the gap?
Respuesta
-
Arg on the head of the reading head
-
Lys on the head of the reading head
-
Val on the head of the reading head
Pregunta 16
Pregunta
UV irradiation of _ causes _?
Respuesta
-
Consecutive pyrimidines
-
Consecutive purines
-
Opens a 5-6 bond
-
Opens a 3-4 bond
-
Opens a 4-6 bond
Pregunta 17
Pregunta
A phosphobutane photo-dimer is formed
Respuesta
- True
- False
Pregunta 18
Pregunta
Why is UV radiation dangerous?
Respuesta
-
It alters DNA conformation
-
So helicases make mistakes
-
Bases are deleted
-
Bases are duplicated
Pregunta 19
Pregunta
How do 6-4 lesions form?
Respuesta
-
An O is transfered from on thymine to another
-
An N is transfered from on thymine to another
-
A C is transfered from on thymine to another
Pregunta 20
Pregunta
Damage is recognised by bases
Respuesta
- True
- False
Pregunta 21
Pregunta
How does photolyase work on 6-4 bonds?
Respuesta
-
Uses light to reverse the reaction
-
Uses UV to reverse the reaction
-
Binds to DNA and excises damaged bases
Pregunta 22
Pregunta
A 'protein wedge' forces DNA apart so it can work
Respuesta
- True
- False
Pregunta 23
Pregunta
An e- from diazaflavin is removed by UV and is passed onto what?
Respuesta
-
FADH
-
NAD
-
NADH
Pregunta 24
Pregunta
The electron will hopefully break the distorted bonds
Respuesta
- True
- False
Pregunta 25
Pregunta
The photolyase process can only work once
Respuesta
- True
- False
Pregunta 26
Pregunta
Which residues bind to the phosphate backbone in photolyase?
Respuesta
-
Glu
-
Arg
-
Gln
Pregunta 27
Pregunta
What does the widowed base pair bind to?
Respuesta
-
Water
-
Methyl
-
ATP
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