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epigenetics
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- 1What does FACT bind to?H2A-H2B dimers and H3-H4 tetramer
- 2how does FACT permit progression of replisomes through nucleosomes• FACT interacts with the replisome: FACT promotes nucleosome disassembly as it collides with nucleosomes.
• FACT is an extremely abundant protein (1 per 5 nucleosome in yeast): FACT could destabilizes nucleosomes ahead of the replisome.
FACT proposed to deposit histones behind the fork
- important to dissect these functions from disassembly
- Both nucleosome disassembly ahead and reassembly behind replication fork may control elongation speed - 3what do ATP- dependent chromatin remodelling complexes doallow access to DNA by altering the structure, composition, and/or position of nucleosomes
• Now recognized as part of most chromatin-based processes including DNA replication -? destabilize or remove nucleosomes ahead of replisomes
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- Fichas sobre epigenetics, creado por Zena Dodds el 10/12/2017.
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- Zena Dodds
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