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Protozoa

Kelly Scott Infectious disease Inglés 30 fichas

Fichas del conjunto (30)

  1. 1Types of protozoansAmoebae
    Ciliates
    Flagellates
    Apicomplexans: all parasitic
  2. 2TrophozoiteActive feeding stage
  3. 3AmoebaeHave a simple lifecycle
    Pseudopodia for movement and engulfing food into vacuoles
    Reproduction via binary fission
    Cyst stage: infective to host, resistant in the environment and contain several nuclei
  4. 4Entamoeba histolyticaLarge intestine of humans, dog, cat, pig and rats
    Faecal-oral transmission
    Mainly a problem in tropical places affecting young and naive animals
    Fatal infection if liver abscesses formed via portal blood system.
  5. 5Naegleria fowleriFree living in hot pools, opportunistic pathogen
    Causes meningoencephalitis. Invasion from nose to brain via cribiform plate and olfactory nerve
  6. 6CiliatesCommon in the rumen
    Balantidium coli:
    In the colon of pigs, humans and primates
    Usually commensal
    If they invade the colon they can ulcerate the colon and form a cyst that is infectious. Has a large nucleus.
  7. 7FlagellatesTrypanosomes
    Spread via insect bites
    Extracellular, mostly in the blood stream
    Single large flagella
    Giardia
    Intestines of healthy animals
    Clinical signs: diarrhoea
  8. 8Giardia morphologyTrophozoite:
    2 nuclei and medial body with large ventral sucker
    Cyst:
    Infective state
    cyst wall encloses partly divided organism with 4 nuclei
  9. 9Trichomonas foetus morphology and reproduction3 forward flagella
    1 undulating membrane
    binary fission reproduction
  10. 10(Tri)Trichomonas foetus diseaseOccurs in genital tract (prepuce) of bulls but causes no disease. Chronic carriers
    When mating with a naive cow they infect the vagina and multiply. They invade the uterus and placenta resulting in abortion 6-8 weeks post mating
    Cows recover and become immune
    Can cause Large bowel diarrhoea in cats
  11. 11Apicomplexans (coccidia)Eimeria sp. in ruminants
    Isospora sp. in cats and dogs
    Infection via direct contact
    Intestinal, intracellular parasite leading to cell death
    Complex lifecycle
  12. 12Sporulation of oocystOocysts develop outside the host, released into the environment
    One sporont becomes 8 sporozoites
    Sporulated oocysts are infective
  13. 13SchizogonyAsexual reproduction
    Sporozoite infects cell
    The nucleus divides repeatedly
    Each nuclei then acquires its own cytoplasm and cell wall forming a schizozoite
    First generation scizozoites form their own generations
  14. 14Male gametogeny2nd generation schizozoite infects host cell forming a microgametocyte
    Microgametes are released from the host cell
  15. 15Female gametogenySecond generation schizozoite infects host cell, forming a macrogametocyte with a macrogamete
    Microgamete fertilises the macrogamete forming an oocyst which is released
  16. 16Apicomplexan parasitesCryptosporidium
    Toxoplasma gondi
  17. 17CryptosporidiumIn domestic animal neonates <10 days old
    Mostly a problem in calves
    Zoonotic
    Oocysts in faeces are immediately infective
    Life threatening for HIV patients
  18. 18Toxoplasma gondiiIndirect transmission between cats (DH) and prey animals (IH)
    Known to cause abortion in sheep, pigs and humans. Most common parasite in developed countries
  19. 19Toxoplasma gondii infectionInfects small intestine and oocysts released in faeces
    In other animals it can break out of the gut and infect other tissues forming cysts
    Ingestion of an oocyst by a rat, sheep or human results in the invasion of cells and rapid multiplication in tissues followed by cyst formation
  20. 20Development in the IHSporozoite infects cell
    Undergoes rapid division
    Forms Tachyzoites
    Tachyzoite infects cell
    Undergoes slow division forming bradyzoites in a cyst (brain, eyes, heart etc)
  21. 21Toxoplasma gondii and foetusesOrganism passes to the foetus where it divides unchecked
    It damages the placenta and foetal nervous system. Can result in abortion and congenital infection and brain damage
  22. 22Toxoplasma gondii human riskInitial infection causes a mild flu
    Cat and sheep faeces are a source of infection
    Has links to psychosis and schizophrenia
    Dangerous for people with HIV/AIDS
  23. 23VaccineLive vaccine with attenuated tachyzoites
    For sheep only
  24. 24Neospora caninumAbortion in cattle via pre-natal infection
    Some hind limb paralysis and paresis in dogs
    Some evidence of abortions in sheep
    Not in humans
  25. 25Neospora canimum lifecycleDH is dogs
    Produce unsporulated oocysts in faeces (few)
    Not known if dogs can shed again if reinfected
    Congenital infection suspected from tachyzoite infection of placenta
    Can cause abortions or a congenital infection
  26. 26EpidemicIntroduction to a naive herd via a dog shedding oocysts
    Abortion storms
  27. 27EndemicCongenital transmission maintains infection
  28. 28Infection in dogsClinical disease in puppies: within a few weeks from birth they get weakness and hind limb paralysis from spinal lesions
    and neurological signs
    Can be treated with early intervention
    Have high neospora antibodies
    Bitches and repeatedly infect litters
  29. 29Theileria clinical signsRecumbent
    severely depressed
    Scant faeces
    Yellow third eyelids or very pale
    On necropsy: pale tissues, thin and translucent blood but normal urine
  30. 30Theileria lifecycleTick transmission
    No transoviarian transimission
    Multiplication in leukocytes then movement into RBC
    Once in the tick it forms gametocytes
    3 host tick

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Infectious disease Fichas sobre Protozoa , creado por Kelly Scott el 13/07/2020.
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Kelly Scott
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