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S08.04

Zoe Fernyhough Inglés 15 fichas

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1HbT vs HbR O2 not boundHbT/HbR = 9000
but in rapid equilibrium
2HbT vs HbR O2 boundHbT/HbR = 3000
but in rapid equilibrium
3HbT preferentially bindsCO2, H+, BPG
4HbR preferentially bindsO2, CO
5Sickle cell causeBeta chain position 6
HbA: glu (- charge)
HbS: val (nonpolar)
6Complementary site in HbA, HbSBOTH deoxyHbA&S have complementary site to val: ala, phe, val (present in HbS)
comp. site not present in oxyHbS or HbA
(subsurface in HbSt) (HbS tight)
binds to OTHER MOLECULE of HbS
7why sickle cell precipitates?HbS deoxy molecules aggregate together, precipitate
8Viscous cycle of HbSdeoxyHbS-->precipitation-->block capillaries/ less blood flow--> more deoxy
9Thalassemiaswrong conc. of beta or alpha subunits
all alpha: precipitation
all beta: low p50, no coop
10CO2 in blood20X more soluble than O2 so 80% in bicarbonate, 12% in deoxyHb
11Carbonic anhydraseIn RBC cytosol
catalyzes rxn. H2O + CO2 --> H2CO3
12disCO2dissolved CO2: CO2 (liq) + H2CO3
13Henderson Hasselbach for CO2
14pCO2 arteries, veinshigher pCO2 in veins, lower in arteries (bc higher pO2)
so pH lower in veins
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