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Electron Transport Chain

Mark Arsenal Exercise Metabolism- Term 1 Inglés 9 fichas

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  1. 1Explain the Malate-Aspartate Shuttle:This is where Oxaloacetate is reduced two Malate where it gains 2 electrons from NADH. Malate (carrying the electrons) crosses into the Matrix whereby it is oxidised donating the 2 electrons tp NAD+ forming NADH Oxaloacetate again in the Matrix which is converted to Aspartate which leaves the Matrix once again. Thus we now have NADH in the Matrix fro ETC breakdown.
  2. 2How does the NADH from Glycolysis (the Cytisol of the cell) enter the ETC?The Inner Mitochondrial Membrane lacks a transport protein allowing NADH from the cytisol to enter the cell, thus we use the Glycerophosphate Shuttle and the Malate-Aspartate Shuttle.
  3. 3Explain the Glycerophosphate Shuttle:NADH cannot cross the Outer Mitochondrial Membrane thus it donates two electrons to Dihydroxacetone Phosphate which forms Glycerol 3 Phosphate which can cross the Outer Membrane. When it reaches the Inner Membrane it donates these carried electrons through Glycerol 3 Phosphate Dehydrogenase to FAD+ in the Inner Mitochondrial Membrane thus forming FADH which enters the ETC cycle through Complex 2.
  4. 4How much energy do NADH and FADH carry?1 NADH carries 10 protons= 2.5ATP per NADH
    1 FADH carries 6 protons= 1.5ATP per FADH
    (4 Protons per ATP)
  5. 5What is the process?Breakdown of energy rich NADH and FADH.
  6. 6Where does the ETC take place?Inner Mitochondrial Membrane
  7. 7What are the 5 complexes?1) NADH Dehydrogenase 2) Succinate- CoQ Reductase 3) Cytochrome B-C1 4) Cytochrome C Oxidase 5) ATP Synthase
  8. 8What are the 2 carriers, and between what complex's do they run?Ubiquinone (Coenzyme Q) Which runs between Complex's 1,2 and 3 (NADH enters through Complex 1 and FADH enters through compex 2) It carries electrons from both complexes to complex 3.
    Cytochrome C Which runs between complex 3 and 4.
  9. 9Brief Explanation of the process:NADH and FADH are high energy electron donors which pass through a series of complex's which creates a proton gradient across the membrane which causes electrons to flow through ATP Synthase to generate ATP.

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(ETC) Exercise Metabolism- Term 1 Fichas sobre Electron Transport Chain, creado por Mark Arsenal el 15/04/2013.
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Mark Arsenal
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