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PHRM20001 Lecture 2 Drug Targets
Fichas del conjunto (14)
- 1Nifedipine- Blocks Calcium Channels
- Reduces blood vessel constriciton
- Reduces Blood Pressure - 2Fluoxitine- Blocks 5-HT reuptake
- Prolongs effects of 5-HT - 3Aspirin- Inhibits Cyclo-Oxygenase (COX)
- Reduces inflammatory response
- Binds covalently - 4L-Dopa- Increases synthesis of Dopamine
- 5Morphine- Activates opioid receptors for pain relief
- 6Naloxone- Opioid receptor antagonist
- Used for heroin overdoses - 7Ionotropic ReceptorsAgonists bind and directly regulate the opening of the ion channel
- 8Metabotropic ReceptorsAgonist binding causes series of intracellular events to indirectly produce effects
- 9Nicotinic ReceptorsLocated on skeletal muscle, and at the preganglionic junction of Para and Sympa neurons.
Ach binds and causes Sodium Channels to open - 10Kinase-Linked ReceptorsAgonist binding causes the activation of the cytoplasmic domain that has Kinase Activity
- 11Cytoplasmic ReceptorsReceptors for lipid-soluble agonists
Agonist-receptor binds and enters the nucleus
Regulates gene expression
e.g. Glucocorticoid Receptors - 12G-Protein Coupled ReceptorsLargest receptor family
Linked to an effector protein by a G-protein
e.g. Muscarinic Receptors - 13GPCR: Adenylate CyclaseProduces cAMP which has activation activity in the cell
- 14GPCR: Phospholipase CCatalyzes PIP2 into Inositol Triphosphate and DAG
Increases intracellular Calcium levels in the cell
Used by Beta Adrenoceptors and Alpha1
Información
- Descripción
- Drugs learnt and Receptors
- Creado por
- Dan McArthur
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