Coagulation

INTRINSIC PATHWAY

EXTRINSIC PATHWAY

Both lead to production of PROTHROMBINASE

Prothrombinase combines with Ca

This catalyses production of PROTHROMBIN

Prothrombin then combines with Ca

This acts as an enzyme to convert FIBRINOGEN to FRIBRIN

Fibrin works to bind together all the previous, platelets, Von Williebrand factors and clotting factors together to make a mesh.

This mesh forms a stable clot

Role of platelets

Adhere to damaged area site

Synthesis arachiodinc acid-> attracting and activating WBC

Synthesis throboxane A -> promotes adhesion and attracts other platelets.

CLOT CONTRACTION- Debated research that the platelets continue to secrete adhesive factors making the clot tighter and reducing the excess fluid.