Lec 6 - 10

1. 1Receptors are usually

   1. Aligands
   2. Btransmembrane
   3. CEMM
   4. Dmessengers
2. 2What is true of receptor based signalling?

   1. Atarget cells contain the receptor which binds specific signals
   2. Breceptors can be cytosolic
   3. Creceptors are stimulated by a hormone or other molecueles
   4. DAll of the above
3. 3What is true of autocrine/paracrine stimuli?

   1. Athe signalling cell and the target cell are the same
   2. Bthe signalling cell and the target cell are different
   3. Ccarried via blood stream to target cell
   4. Dboth ligand and receptor are membrane bound on cells in close proximity
4. 4a signal that's carried through the body via the blood stream to target cells throughout the body is

   1. Aautocrine
   2. Bendocrine
   3. Cjuxtocrine
   4. Dparacrine
5. 5What is false about juxtacrine?

   1. Ahave shot distance b/w cells
   2. Bboth ligand and receptor are membrane bound
   3. Coften for survivial and proliferation
   4. DB & C
6. 6What happens upon prolactin binding?

   1. Atwo receptor chains dimerize
   2. Breceptors bind to ligand
   3. Ca receptor chain forms a trimer
   4. DB & C
7. 7What is false about JAK?

   1. Aphosphorylated the receptor to create docking site
   2. Bit autophosphrylates
   3. Cphosphorylates STAT molecules
   4. Dforms dimers of two receptors
8. 8What is true about the principles of GPCR signalling?

   1. Athe receptor undergoes a conformational change when activated or deactivated
   2. BG-protein help activate specific effector molecules
   3. Cdo not required the association of a G-protein
   4. DA & B
   5. EB & C
9. 9G-proteins regulate signal events by

   1. Aexisting as two interchangeable states of GTP & GDP
   2. Bbeing held at the plasma membrane by lipid changes that are covalently attached to the alpha and gamma subunits
   3. CBy hydrolysis
   4. DA & B
10. 10What is false of the two states of G - proteins?

    1. AThe active is GTP bound and inactive is GDP bound
    2. Ban active G-protein becomes inactive by hydrolysis
    3. Cphosphorylation is needed to interchange b/w the two forms of G- proteins
    4. DGDP bound can become GTP bound

11. 11What is false about heterotrimeric G - proteins?

    1. Athey work w GPCR to replay signals
    2. Bhave 3 diff subunits called beta, alpha, and gamma
    3. Cthe alpha and beta subunits are linked to lipid chains covalently to hold the G - proteins to the plasma membrane
    4. DB & C
12. 12What happens when a ligand binds to a receptor in G - protein activation?

    1. AIt creates a conformational change
    2. Bdecreases receptor's affinity for G - protein
    3. CBeta subunit replaced GDP with GTP
    4. DA & C
13. 13Which subunit creates the nucleotide exchange and of which type, in the G-protein activation stages?

    1. ABeta. GDP --> GTP
    2. BBeta, ATP --> ADP
    3. CGamma, GTP --> GDP
    4. DAlpha, GDP --> GTP
    5. EAlpha, GTP --> GDP
14. 14During the G - protein activation, a 2nd messanger is produced. What is it?

    1. Aeffector
    2. BcAMP
    3. CRAF
    4. DFAK
    5. EiCAMP
15. 15Which molecules causes the G - protein activation to end signalling?

    1. AArrestin
    2. BGRK
    3. CGlucose
    4. DCREB
16. 16__________ phosphorylates GPCR and recruits arrestin

    1. ASARC
    2. BGRK
    3. CG alpha subunit
    4. DGPK
17. 17In glucose modification, heterotrimeric G - protein activates _______________ which catalyzes ________________ from ______________

    1. Aadenylyl cyclase, cAMP, ATP
    2. Badenylyl cyclase, Raf, ATP
    3. CATP, cAMP, GRK
    4. DArrestin, termination, GRK
18. 18In signal amplification,

    1. Aa single hormone can activate multiple proteins
    2. BcAMP an be stoped/destroyed by phosphodiesterase
    3. CcAMP can only activate PRA
    4. DA & B
    5. EA & C
19. 19Which of the following is not a characteristic of 2nd messengers?

    1. Asome of them are generated from lipids
    2. BCalcium is an example that can act as a 2nd messenger
    3. CIt binds to a single receptor
    4. Dstimulates cellular activity
20. 20What is true about the PH domain?

    1. Aused by PLC to interact with phophorylated histone rings
    2. Bcan bind to head group of phospholipid
    3. Chelps functioning of 1st messenger
    4. DA & B
21. 21Which of the following does activation of GPCR by acetylcholine not requires?

    1. Aacetylcholine binding to GPCR to stimulate smooth muscle contraction
    2. BG-protein to activate PLC which produces only IP3
    3. CDAG to activate protein kinase- C pathway
    4. DA & B
22. 22IP3 receptor is

    1. Aa ligand - gated calcium channel
    2. Bopening the chanel of IP3 receptors to allow calcium ions into cytoplasm
    3. Callowing G proteins to hydrolyze
    4. DA &B
    5. EAll of the above
23. 23What is the effector protein in the pathway of IP3 production?

    1. APKA
    2. Bphospholipase C
    3. CAdenylyl cyclase
    4. Ddiacylglycerol
    5. EPIP2
24. 24What is true regarding receptor tyrosine kinases?

    1. Athey posses tyrosine kinase activity within a domain of the receptor amino-acid chain
    2. Ba kinase activity is activated by a second messenger binding to a receptor
    3. Cno conformational changes occur to activate kinase activty
    4. Dkinase is activated by phosphrylation
25. 25receptor tyrosine kinases (RTKs) are directly activated by __________ and have _____________

    1. Aextracellular signals, ligand-binding domain
    2. Bligand-mediated dimerization, ligand-binding domain
    3. Cligand-mediated dimerization, extracellular signals
    4. Dextracellular signals, ligand-mediated dimerization
26. 26which kinase is regulated indirectly by extracellular signals?

    1. ACytoplasmic protein tyrosine kinase
    2. BReceptor tyrosine kinase
    3. CcAMP
    4. Dligand mediated kinase
27. 27what are the ways receptors can be be brought together?

    1. Aligand mediated dimerization
    2. Breceptor mediated dimerization
    3. Ceffector mediated dimerization
    4. Dsignal mediated dimerization
    5. EA & c
    6. FA & b
    7. GB & D
28. 28ligand meditated is

    1. Aone ligand w 2 receptor binding sites
    2. Beach receptor chain binds one ligand
    3. Cdimerization is inactive at one point
    4. DA & C
29. 29What are the functions of autophosphorylation sites on receptor?

    1. Aregulate kinase activity
    2. Bfunction as docking sites for signalling molecules
    3. Cact as activating factors
    4. DAll of the above
    5. EA & B
30. 30Which domain binds to phosphorylated tyrosine?

    1. ASH2 domain
    2. BSH3 somain
    3. CPTB domain
31. 31Which domain binds to hydrophobic prolines?

    1. ASH2
    2. BSH3
    3. CPTB
32. 32Which domain binds to phosphotyrosine - binding?

    1. ASH2
    2. BSH3
    3. CPTB
33. 33Which of the following is an adaptor protein?

    1. AGrb2
    2. BIRS
    3. CSTAT
    4. DSOS
34. 34Which of the following is a docking protein?

    1. AIRS
    2. BSTAT
    3. CSOS
    4. DShp2
35. 35RAS is a small monomeric G- protein. Which of the following is false?

    1. ASOS is a GAP for the Ras
    2. BGEF modulates the activity of it
    3. Cuses GAP and GDI
    4. DMutation is the Ras keeps it in off position
36. 36What does GAP do?

    1. Astiulates hydrolysis of bound GTP to GDP
    2. Bdecreases duration of signal
    3. Cinhibits release of bound GTP
    4. DAll of the above
    5. EA & B
37. 37What is RAS?

    1. ASmall GTPase held at the inner surface of the membrane
    2. BMutation in RAS allows GTP hydrolysis
    3. CExchanges GDP to GTP
    4. DInhibits the release of GDP
38. 38Phosphorylated tyrosines form docking sites on active receptors. Identify a protein domain that binds phosphorylated tyrosines

    1. APTB
    2. BSH2
    3. CSH3
    4. DPH
    5. EA & B

Descripción

(BIO 331) Biology Test sobre Lec 6 - 10, creado por Malaika Abid el 05/04/2018.

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Malaika Abid

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