Test
NSAIDs
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Preguntas del test (21)
1Why are some NSAIDs known as 'Traditional'?
- AThey only block one COX
- BThe block both COXs
2Describe COX1
- AConstituative
- BInducible
- CMembrane bound
- DCytoplasmic
3The channels of both COX1 & COX 2 are constricted to prevent incorrect substrate binding
- AVerdadero
- BFalso
4Where do NSAIDs bind on COX 1?
- AArg 120
- BArg 130
- CArg 140
5Aspirin binds permenantly to the Ser 530 of COX1
- AVerdadero
- BFalso
6Why does COX2 have a much wider channel than COX 1?
- AVal533 forces the channel to be wider
- BSer533 forces the channel to be wider
- CIle533 forces the channel to be wider
7COX2 is inducible
- AVerdadero
- BFalso
8The smaller channel of COX2 can be used for selective inhibition- i.e. Colecoxib
- AVerdadero
- BFalso
9COX2 is much less responsible for inflammation than COX1
- AVerdadero
- BFalso
10Why are selective COX2 inhibitors used on patients with G.I troubles?
- AThey also repair mucus membranes
- BThey have fewer side effects
- CThey cannot be digested properly by healthy tracts
11What is the most common side effect of NSAIDs?
- AGI troubles
- BRenal insufficiency
- CC.V disorders
12Aspirin is the only NSAID thought not to cause cardiovascular disorders
- AVerdadero
- BFalso
13Name the two NSAID side effects that contribute to cardiovascular disorders
- AInc salt and water retention
- BConstant vasoconstriction effect endothelium
14Cole/Paracoxib are traditional NSAIDs
- AVerdadero
- BFalso
15What is the effect of Aspirin in platelets?
- AReduced Thromboxin A2
- BReduced Thromboxin I2
- CReduced Thromboxin E2
16The binding of aspirin lasts for the entire life of the platelet
- AVerdadero
- BFalso
17To whom can Aspirin not be given?
- AOver 65s
- BPregnant women
- CChildren under 16
18Paracetamol is anti-inflammatory but not antipyretic
- AVerdadero
- BFalso
19The action of paracetamol is unknown
- AVerdadero
- BFalso
20Why is paracetamol toxic to the liver in high doses?
- AOversaturates the removal pathway
- BCausing an alternative to be used
21The alternative paracetamol removal pathway causes an increase in toxic NAPQ1
- AVerdadero
- BFalso
Información
- Descripción
- Year 2 Test sobre NSAIDs, creado por gina_evans0312 el 30/01/2014.
- Autor
- gina_evans0312
- Idioma
- English
- Visitas
- 1.075
- Etiquetas
- Valoración
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