Flashcards
cellular adhesion
Cards in this deck (12)
- 1What are the 4 types of cell junction?Anchoring
Occluding
Channel-forming
Signal-relaying - 2Name the families of cell adhesion molecules that mediate Cell:Cell adhesionClassical cadherins
Desmosomal Cadherins
Ig family members
Selectins
Integrins - 3Name the families of cell adhesion molecules that mediate Cell:Matrix adhesionIntegrins
Transmembrane proteoglycans - 4CadherinsLink to actin cytoskeleton or intermediate filaments and mediate Ca2+ dependent adhesion
- 5Immunoglobulinsmediate Ca2+ independent adhesion
- 6SelectinsLink to actin cytoskeleton
- bind mucin
- Ca2+ dependent - 7Name some of the processes that are controlled by cell adhesion molecules- They allow circulating T cells to home to lymph nodes
- the recruitment of neutrophils to infected tissues - 8what type of cell adhesion molecule is regulated by inflammation?selectins
- 9IntegrinsMediate adhesion of cells to the ECM & Cell:cell adhesion
- signal transducing receptors - 10How is integrin activated by outside-in signalling?dimer adopts folded structure & becomes activated by ligand binding. It can them break the interaction between cytoplasmic tails, exposing binding sites for cytoskeleton attachment.
- 11How is integrin activated by inside-out signalling?intracellular signalling activates talin, which competes for binding to cytoplasmic tails and pushes subunits apart. The extracellular portion adopts extended conformation and has a higher affinity for ligand.
- 12What are hemidesmosomes?anchoring junctions that link extracellular laminin in basement membrane to keratins within epithelial cells
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- Biochemistry & cell biology (cell adhesion & cell signalling) Flashcards on cellular adhesion, created by Sophia Puliasis on 30/11/2017.
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- Sophia Puliasis
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