12790924
Description
Flashcards by James Sante, updated more than 1 year ago
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Created by James Sante
about 6 years ago
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| Question | Answer |
| ANC Formula | [ ( % segs + % bands ) / 100 ] x WBC |
| BSA Formula | Sq Rt of [ ( kg x cm ) / 3600 ] |
| Inches (in) --> Centimeters (cm) | in x 2.54 = cm |
| Pounds (lb) --> Kilograms (kg) | lb / 2.2 = kg |
| Drugs associated w/ pneumonitis & pulmonary fibrosis | Bleomycin; Busulfan; Methotrexate |
| Brand of busulfan | Busulfex |
| Brand of methotrexate | Trexall; Rheumatrex |
| Brand of bleomycin | Blenoxane |
| Generic of Platinol-AQ | cisplatin |
| Generic of Adriamycin | doxorubicin |
| Cardiomyopathies | Doxorubicin (Adriamycin) |
| 2 "types" of dexrazoxane | Zinecard = Prophylaxis of doxorubicin-induced cardiomyopathy; Totect = Treatment of anthracycline extravasation |
| Cell Cycle Specific Agents | Vincas; Taxanes; Topo-Inhibitors; Pyrimidines; Folate Antimetabolites |
| Vinca Alkaloids ("Vincas") | Vinblastine; Vincristine; Vinorelbine |
| Vincristine | Top3 TidBits = (1) 2 mg/dose cap; (2) Constipation; (3) Use WARM compresses [not cold] if extravasation |
| Vinblastine | Top2 TidBits = (1) Myelosuppressive [as well as vinorelbine]; (2) Use WARM compresses |
| Taxanes | Docetaxel; Paclitaxel |
| Docetaxel = Taxotere | Top3 TidBits = (1) Severe fluid retention; (2) Infusion-related HSR; (3) Peripheral sensory neuropathies |
| Paclitaxel = Taxol | Top2 TidBits = (1) Premedicate w/ diphenhydramine, corticosteroid, H2RA; (2) Albumin-bound version "Abraxane" needs no premedication [i.e. low allergic reaction] |
| Topoisomerase I Inhibitors (Topo1-Inhibitors) | Irinotecan; Topotecan |
| Irinotecan = Camptosar | Top4 TidBits = (1) N/V/*D*; (2) Homozygous for UGT1A1*28 at inc. risk for neutropenia, delayed diarrhea; (3) Use only when ANC > 1,500; (4) Myelosuppression |
| Topotecan = Hycamtin | Top2 TidBits = (1) Use only when ANC > 1,500 and PLT > 100,000; (2) Myelosuppression |
| Topoisomerase II Inhibitors (Topo2-Inhibitors) | Etoposide CAPSULES; Etoposide IV; Etoposide Phosphate |
| Etoposide CAPSULES = VePesid | Require refrigeration (RARE!); Divide doses > 200 mg; Myelo; HSR |
| Etoposide IV = Toposar | Rate-related hypotension (i.e. infuse over 30-60 minutes); Non-PVC bag/tubing due to DEHP leaching |
| Pyrimidine Analog Antimetabolites ("Pyrimidines") | Fluorouracil ("5-FU"); Capecitabine; Cytarabine; Gemcitabine |
| Fluorouracil (5-FU) = Adrucil | Top3 TidBits = (1) Given w/ LEUCOVORIN to inc. EFFICACY (think *booster*); (2) DPD deficiency inc. risk of severe toxicity; (3) "Efudex" brand also used for BCC |
| Capecitabine = Xeloda | Top3 TidBits = (1) C/I in CrCL < 30 mL/min); (2) PO prodrug of 5-FU; (3) ***HAND-FOOT SYNDROME*** |
| Cytarabine = "ara-C" | "Cytarabine Syndrome" (fever, flu-like, myalgia, bone pain, rash); Pulmonary toxicity; ***HAND-FOOT SYNDROME*** |
| Folate Antimetabolites | Methotrexate (MTX); Pemetrexed |
| MTX = Trexall; Rasuvo; etc. | "High-Dose MTX" (> 500 mg/m^2) requires LEUCOVORIN "rescue"; *HYDRATION* & *NaHCO3* to dec. nephrotoxicity risk; Glucarpidase (Voraxaze) is the expensive rescue agent |
| METHOTREXATE DOSING | Cancer Dosing is MUCH HIGHER than Rheumatoid Arthritis or Psoriasis Dosing --> Daily v. Weekly (respectively) |
| Pemetrexed = Alimta | Give folic acid, vit. B12, dexamethasone to dec. risk of side effects |
| INTRATHECAL administration of MTX... | Use ONLY the ***Preservative-Free*** formulation!!! |
| M Phase Agents --> (These inhibit microtubule function...) | Vincas (vinblastine, vincristine); Taxanes (docetaxel, paclitaxel) |
| S Phase Agents | Topo1-Inhibitors (irinotecan, topotecan); Pyrimidines (5-FU, capecitabine, cytarabine, gemcitabine); Folate Antimetabolites (MTX, pemetrexed) |
| G2 Phase Agents --> (There is only one...) | Topo2-Inhibitors (etoposide) |
| Any phase-specific cancer drug that can cause pulmonary complications (e.g. pneumonitis, fibrosis, toxicity, etc.) | Bleomycin; Busulfan; MTX; Cytarabine (*toxicity*) |
| Phase-specific cancer drugs in which a "dose cap" or "pre-requisite" should be associated | Vincristine (2 mg/dose cap); Irinotecan = Camptosar (ANC must > 1,500); Topotecan = Hycamtin (ANC must > 1,500; PLT must > 100,000); Capecitabine = Xeloda (C/I in CrCL < 30); MTX (>500 mg dose BSA req. Leucovovrin and/or Glucarpidase = Voraxaze) |
| "Rare capsules" that require refrigeration | Etoposide = VePesid |
| Biggest culprit of hand-foot syndrome | Capecitabine = Xeloda; Cytarabine = "ara-C" |
| LEUCOVORIN pairings... | If leuco is given w/ 5-FU = ***BOOSTER*** If leuco is given w/ MTX = ***RESCUER*** |
| Which of the Taxanes typically requires pre-medication? | Paclitaxel = Taxol [However, albumin-bound Abraxane needs no pre-medication!] |
| The AE profile of Platinol-AQ (cisplatin)... | N/*V*/D; Dose-limiting nephrotoxicity; Ototoxicity (e.g. tinnitus); Neurotoxicity |
| Maximum Lifetime Dose of Adriamycin (doxorubicin)? | 550 mg dose BSA |
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