Flashcards
Learning II
Cards in this deck (16)
- 1Cerebellum is involved inMotor learning
- 2What are the major inputs to the Purkinje cells?Parallel fibres
Climbing cells - 3What are the major inputs to the granule cells?Mossy fibres
- 4How do you induce cerebellar LTD experimentally?Stim. climbing and parallel fibres
- 5Diagram of thismV
t from pairing
Conditioning - 6What is the mechanism of LTD?Pairing causes ^ Ca++ IC
This enables PKC to + AMPAR
AMPAR are internalised, so cell is less excitable - 7Where is the Hippocampus found?In the medial temporal lobe
- 8R Hippocampus / L HippocampusR = Learning + recall of spacial enviro
L = Dominant for word recall - 9What's Hebb's postulate?If cell A is involved in persistently firing cell B, then a growth process will occur in one or both cells so that A's efficiency in firing B increases
- 10LTPLong-term potentiation
Application of a single high frequency stimulus results in a persistent increase in response size - 11What are the three major afferent pathways in the hippocampus?Perforant fibre pathway (associate LTP)
Mossy fibre pathway (Non-a LTP)
Schaffer collateral pathway (A LTP) - 12Hippocampal pathwayPerforant fibre pathway -> dentate gyrus cells -> Mossy fibre pathway -> CA3 -> Shaffer collateral pathway -> CA1
- 13What receptors can glutamate bind?Ionotropic NMDAR and AMPAR
- 14Low level stimulationGlutamate binds AMPAR
AMPAR open
Na+ in
EPSP generated
EPSP not strong enough to remove Mg2+ binding to NMDAR - 15Strong stimulationLarge amount of glutamate
Opens many AMPAR
large Na+ in causes depolarisation
Mg2+ dissociates
Glutamate binds NMDAR
Ca++ flows through AMPAR - 16What is this process known asInduction of Long-term potentiation
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- Flashcards on Learning II, created by J yadonknow on 10/05/2018.
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- J yadonknow
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