Flashcards
Toxicology
Cards in this deck (6)
- 1Overpredictions for initial concentrationsinaccurate history of dose
innacurate time interval - 2Overprediction for initial concentrations-Early sampling with minimal time for product dissolution and absorption to occur
-low absorption (positive outcomes from gastric emptying events)
-delayed/incomplete absorption (poorly water soluble products) - 3Underpredictions for initial concentrations-Inaccurate history of dose (historical data low dose)
-inaccurate time interval (historical data too long)
-alterations in absorption (dose dumping of sustained release dosage forms)
-early sampling during distribution phase, but Cp is calculated using post-distribution Vd - 4Underpredictions for subsequent concentrations-alterations in absorption (dose-dumping of sustained release dosage forms)
-Bezoar dissolution endogenous metabolism and/or elimination is slower than known population values
-calculated patient-specific Ke was predistribution not during true elimination
-ineffective decontamination or elimination-enhancement therapies, and/or unaccounted new administration - 5How to reduce toxicity?1. prevent absorption
2. Antidotes
3. Enhanced elimination - 6Examples of Preventing absorptionEmesis, gastric lavage, activated charcoal, whole bowel irrigation
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- Flashcards on Toxicology, created by Fatin Nabilah Roslaile on 24/05/2018.
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- Fatin Nabilah Roslaile
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