1767039
Description
Flashcards by mary nguyen, updated more than 1 year ago
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Created by mary nguyen
about 11 years ago
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| Question | Answer |
| measles virus (paramyxoviridae) | highly contagious preventable though vaccination - SS RNA helical symmetry nucleocapsid envelope |
| Calicivirus | is the reason why there are virus particles found in water even though water is not "alive" |
| endogenous retroviruses (HERVs) | remnants from infections that occurred millions of years ago and are no longer infectious |
| polydnavirus | suppress innate immune response of larva so the wasp eggs can thrive is transmitted when wasps deposit eggs in caterpillaz |
| curvulara thermal tolerance virus (CThTV) | allows curvularia protuberata (a fungus) to grow in temps >50 degrees the fungus, in turn, permits plant survival |
| potyvirus | makes broken tulip pattern |
| tobacco mosaic virus | used in expts to show that viruses 1) cannot be filtered out 2) need a fresh host rod shaped helical symmetry |
| mimivirus | amoeba is host can be seen under a light microscope, unlike most viruses |
| JC virus (polyomaviridae) | small (5 kbps) double stranded (ds) DNA genome immune system usually deals with this OK but immunosup ppl get degenerative brain disease uses RNAP of host |
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adenovirus (adenoviridae family)
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adeno.PNG (image/PNG)
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large double strnaded (ds) DNA genome respiratory and gastrointestinal infections in humans RNAP in host enters thru conjunctiva |
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variola virus (poxviridae)
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pox.PNG (image/PNG)
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extra large (350 kbps) double stranded (ds) DNA genome causes smallpox RNAP in virus |
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Hep B (hepadnaviruses)
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hep_b.PNG (image/PNG)
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gapped double stranded (ds) DNA genome viral DNAP host RNAP use coat proteins for vaccine (non-infectious but immunogenic) |
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parvoviridae
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single stranded DNA genome host DNAP host RNAP cat/dog infections - intestine, hematopoietic system, fetus --> kills puppies |
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rotavirus (reoviridae)
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rota.PNG (image/PNG)
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most important cause of gastroenteritis worldwide ds RNA genome viral RNAP |
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poliovirus (picornaviridae)
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picorna.PNG (image/PNG)
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(+) SS RNA genome poliovirus causes paralytic poliomyelitis: inflammation of motor neurons of spinal cord and brain stem non enveloped virus with icosahedral symmetry (60 VP1, 60 VP2, 60 VP3 -- 60 faces of 3 proteins each) injects RNA directly across plasma membrane after conformational change in capsid protein (hydrophobic N -termini of VP1 insert into membrane to make channel) |
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Hep A (picornaviridae)
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picorna.PNG (image/PNG)
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(+) RNA genome enters thru alimentary tract spread to liver -> cause jaundice zoonotic -- get from shellfish |
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influenza virus (orthomyxoviridae)
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ortho.PNG (image/PNG)
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(-) SS RNA hemagglutinin viral envelope glycoprotein that binds sialic acid human -- 2-6 sialic (upper and lower RT) and birds 2-3 sialic (lower RT only) specific pH (7) triggers elongation of fusion proteins and formation of trimers --> pulls host membrane towards viral membrane to make channel for intracellular release |
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Ebola (filoviridae)
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filo.PNG (image/PNG)
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(-) SS RNA viral RNA-dep RNAP = L protein nucleocapsid helical symmetry release at late endosomal compartments glycoprotein binding activates cathepsins uses NPC1 to enter cell |
| simian virus 40 | icosahedral virus that demonstrates polyhedral symmetry |
| HPV (human papilloma virus) | use coat proteins for vaccine (non infectious but immunogenic) |
| vesicular stomatitis virus | helical symmetry nucleocapsid |
| norwalk virus | larger virus with icosahedron shape (almost) quasiequivalent (almost perfectly symmetrical) |
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reovirus (reoviridae)
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reo.PNG (image/PNG)
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non enveloped virus EE pH causes loss of capsid, LE pH causes holes LE, leading to membrane penetration and release of the core |
| HIV | conical nucleocapsid capsid envelope + RNA genome |
| SIV-cpz | simian immunodeficiency virus that is sexually transmitted in chimps clusters with HIV M came from chimps eating old world monkeys |
| dengue virus (flaviridae) | envelope tropical disease, transmitted by mosquitoes fusion at the acidic pH of a late endosome enters by endocytosis |
| west nile (flaviridae) | an example of inapparent infection + RNA genome envelope |
| herpesviridae | use microtubule motors to enter the nucleus b/c it's a large virus and can't get thru nuclear pore complexes |
| herples simplex virus | causes herpes galdiatorum (transmitted thru wrestling) |
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