Flashcards
Liver function tests
Cards in this deck (9)
- 1Liver jobs- Metabolism of bilirubin, protein, carb, hormones, fat & drugs & alcohol
- storage of vits and Fe
- activation of vit D - 2Liver biochemistry testing uses- Screening
- diagnosis
- severity of disease e.g. acute or chronic
- prognosis
- disease monitoring - 3bilirubin metabolsm 1Hb - haem and globin - Fe2+ and bilirubin (insoluble and albumin bound so unconjugated)
- 4bilirubin metabolism 2 in liverAlbumin separates from unconjugated bilirubin - bilirubin joins to glucoronic acid so becomes soluble and conjugated (bilirubin glucoronide)
- 5Bilirubin metabolism 3 excreted in bile and now in large intestineconjugated bilirubin - urobilinogen, stercobilinogen & stercobilin - lost in poo.
Some reabsorbed and lost in urine as urobilinogen (yellow) - 6unconjugated vs conjugated- insoluble & soluble
- tight bind albumin & not
- not & can be excreted in wee
- fatty tissue deposit & long time to albumin bind
- indirect & direct - 7Pre-Hepatic Hyperbilirubinaemia unconjugated- haemolytic anaemia and ineffective erythropoiesis
- kernicterus in neonatal as uncon bili passes BBB and accumulates in brain. - 8Hepatocellular Hyperbilirubinaemia high uncon & con bili- liver can't take uncon bili
- cirrhosis or hepatitis
- congenital enzyme deficiency so gilbert's syndrome
- dublin johnson syndrome due to high con bili - 9Cholestatic Hyperbilirubinaemia con : uncon bili impaired - intrahepatic - extrahepatic- cholestasis where bili trapped in liver due to cirrhosis or hepatitis
- bili builds in canaliculi & gall bladder due to gall stones tumours.
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- unii BIOL 281: Clinical biochemistry Flashcards on Liver function tests, created by Jumael Zafar on 17/10/2019.
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- Jumael Zafar
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