21853082
Description
Flashcards by Sam Adeyiga, updated more than 1 year ago
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Created by Sam Adeyiga
about 4 years ago
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| Question | Answer |
| Adjuvant drug for Stage 1A Cancer ER(+), PR(+) | Endocrine therapy |
| Adjuvant drug for Stage 1A Cancer ER(-), PR(-) | +/- Chemotherapy |
| Adjuvant drug for Stage IB - III Cancer ER(+), PR(+), HER2(+) | Chemotherapy + Trastuzumab + Endocrine therapy +/- pan-EGFR |
| Adjuvant drug for Stage IB - III Cancer ER(+), PR(+), HER2(-) | Chemotherapy + Endocrine therapy |
| Adjuvant drug for Stage IB - III Cancer ER(-), PR(-), HER2(+) | Chemotherapy + Trastuzumab +/- pan-EGFR |
| Adjuvant drug for Stage IB - III Cancer ER(-), PR(-), HER2(-) | Chemotherapy |
| Adjuvant drug for IV Cancer ER(+), PR(+), HER2(+) | Chemotherapy + Trastuzumab/Lapatinib + Endocrine therapy |
| Adjuvant drug for IV Cancer ER(+), PR(+), HER2(-) | Chemotherapy + Endocrine therapy +/- CDK4/6 inhibitor |
| Adjuvant drug for IV Cancer ER(-), PR(-), HER2(+) | Chemotherapy + Trastuzumab/lapatinib |
| Adjuvant drug for IV Cancer ER(-), PR(-), HER2(-) | Chemotherapy |
| Premenopausal women with hormone receptor–positive [ER (+), PR(+)] tumors, treat w/ .... | tamoxifen for 5 to 10 years |
| Women who are known to be in menopause at any age, and who have hormone receptor–positive [ER (+), PR (+)] tumors, treat w/ ... | 1. initial trt = 5 yrs of aromatase inhibitors (AIs) +/- tamoxifen 2. AIs are known to increase PFS (not OS) |
| If a woman on tamoxifen becomes post-menopausal within 5 years of starting tamoxifen (either naturally or due to oopherectomy), what do you do? | switch from tamoxifen to an aromatase inhibitor |
| Preferred Single Agents for stage IV chemotherapy (Anthracyclines) | 1. Doxorubicin 2. Epirubicin 3. Pegylated liposomal doxorubicin |
| Preferred Single Agents for stage IV chemotherapy (Taxanes) | 1. Paclitaxel +/- Bevacizumab 2. Docetaxel 3. Albumin-bound paclitaxel |
| Preferred Single Agents for stage IV chemotherapy (Antimetabolites) | 1. Gemcitabine 2. Capecitabine |
| Preferred Single Agents for stage IV chemotherapy (Microtubule inhibitors) | 1. Vinorelbine 2. Eribulin 3. Ixabepilone (taxane & anthracycline failures) |
| Preferred Combination Regimens for stage IV chemotherapy (1) | 1. cyclophosphamide/doxorubicin/fluorouracil (CAF/FAC) 2. fluorouracil/epirubicin/cyclophosphamide (FEC or CEF) 3. doxorubicin/cyclophosphamide (AC or CA) 4. epirubicin/cyclophosphamide (EC or CE) |
| Preferred Combination Regimens for stage IV chemotherapy (2) | 1. doxorubicin/docetaxel or doxorubicin/paclitaxel (AT) 2. cyclophosphamide/methotrexate/fluorouril (CMF) 3. gemcitabine/paclitaxel (GT) 4. docetaxel/capecitabine |
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