21981094
Description
Flashcards by Sam Adeyiga, updated more than 1 year ago
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Created by Sam Adeyiga
about 4 years ago
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| Question | Answer |
| Foscarnet (Foscavir®) is a chemical analog of ------- | pyrophosphate |
| Foscarnet (Foscavir®) MOA | 1. it binds to pyrophosphate binding site and block the pyrophosphate binding site on viral DNA polymerase. 2. It prevents the cleavage of pyrophosphate from deoxynucleoside triphosphates and, in turn, the elongation of the viral DNA chain. |
| Foscarnet (Foscavir®) is selective for viral DNA polymerase of two herpseviridae. These are -----? | 1. HSV 2. cytomegalovirus (CMV). |
| Foscarnet (Foscavir®) major AEs are ----? | 1. renal impairment 2. seizures 3. hypocalcemia 4. hypophosphatemia 5. hypomagnesemia 6. hypokalemia 7. hyperphosphatemia |
| To decrease renal toxicity ----------- shd be administered prior to and during foscarnet therapy. | I.V. hydration |
| What is foscarnet prego category? | Cat. C |
| Cidofovir (Vistide®) MOA | 1. It inserts into DNA chains it acts as a faulty base and terminates DNA synthesis. 2. MOA is similar to that of Acyclic Nucleoside Analogs. Hence, it causes chain termination. |
| Cidofovir (Vistide®) is active against ------------------ ? | HSV resistant to the “cyclovirs” CMV |
| Cidofovir (Vistide®) has high renal toxicity, to minimize renal toxicity, two steps must be taken. These steps are ---------? | 1. IV hydration therapy before and during cidofovir therapy 2. administration of probenecid with cidofovir. |
| What are the effects of coadministration of probenecid? | 1. blocks renal tubular secretion of drugs 2. decreases the exposure of the kidneys to cidofovir at sites of tubular secretion 3. decreasing the risk of renal toxicity. |
| Probenecid is sometimes administered with penicillin G, a drug with a short half-life that is eliminated extensively by renal tubular secretion. Why? | 1. Penicillin used to be prescribed with probenecid to decrease amount of penicillin needed to treat infections. 2. Blocks renal excretion of antibiotic causing increased level of penicillin |
| Cidofovir pregnancy category is ---------- ?. | Cat. C |
| What is Podofilox (Condylox®) administration and why? | 1. It is administered topically as a solution or gel. 2. This is due to risk of potent cytotoxic toxicity when administered systemically. |
| Podofilox (Condylox®) indications include ----- ? | 1. HPV 2. genital warts |
| Imiquimod (Aldara®, Zyclara®) is available as a ---------- formulation. | topical cream |
| Imiquimod (Aldara®, Zyclara®) MOA? | 1. Immune-response modifier 2. activates receptors in the immune system that subsequently increase production of immune factors important to the immune response against viruses. |
| administration of Imiquimod (Aldara®, Zyclara®) is limited to --------------- duration? | 3 X per week |
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