22032964
Description
Flashcards by Evian Chai, updated more than 1 year ago
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Created by Evian Chai
about 4 years ago
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| Question | Answer |
| What is soft connective tissue? | Cells embedded in an extracellular matrix |
| What are the 6 functions of soft connective tissue? | 1. Space filler 2. Mechanical support 3. Attachment/protection 4. Nutrient highway 5. Calcium/fat storage 6. Immunological defense |
| What are the 4 types of soft connective tissue? What are their functions? | 1. Mesenchyme (embryonic) 2. Loose (under dermis) 3. Reticular (bone marrow/lymph 4. Adipose |
| Which 3 indigenous cells are present in the ECM? | 1. Fibroblasts that secrete ECM proteins 2. Adipocytes for fat storage/leptin release 3. Mast cells for immunological defense |
| What ECM proteins do fibroblasts secrete? | 1. Adhesive proteins 2. Collagen 3. Elastin |
| What immigrant cells are in the ECM of soft connective tissue? | 1. Lymphocytes 2. Basophils 3. Eosinophils 4. Dendrite cells 5. Neutrophils 6. Monocytes/macrophages |
| What is the ECM made up of? | 1. Collagen 2. Ground substance 3. Proteoglycans 4. Glycoaminoglycans (GAGs) 5. Polysaccharides 6. Elastic fibers 7. Adhesive glycoproteins |
| What type of collagen is the most dense, and found in fibrous connective tissue such as bones, tendons, and dentine? | Type 1 |
| What type of collagen is the most flexible, and found in blood vessels/skin? | Type 3 |
| What type of collagen is for flexibility and movement, and found in cartilage? | Type 2 |
| Where is Type 4 (sheet) collagen found? What is unique about its structure? | In the basement membrane No fibril/triple helix, mesh network |
| What is the structure of collagen? | Triple helix in fibrils |
| What is the ground substance? | Water stabilised by GAGs, proteoglycans, glycoproteins |
| What are glycoaminoglycans (GAGs)? | long sugars that are acidic to attract H20 |
| What do glycoaminoglycans do? | Shock absorbant Lubricant |
| What is the difference between GAGs and proteoglycans? | Proteoglycans are GAGs covalently linked to protein |
| What are elastic fibers made of? Where are they found? | Made of elastin/fibrillin Found in skin, lung, blood vessels |
| When are elastic fibers synthesised and what is their function? | Synthesised at birth Function is to extend, store energy when stretched |
| What are adhesive glycoproteins and what do they do? | Intermediaries that bind cells via their cell surface integrin receptors Helps form ECM |
| What are 3 examples of adhesive glycoproteins that cells bind to? | 1. Fibronectin 2. Tenascin (wound healing) 3. Laminin (binds epithelia to basement membrane) |
| Why do GAGs attract water? | They are negatively charged sugars |
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