cardiovascular-modified-release-designs

jjschneider
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jjschneider
Created by jjschneider over 4 years ago
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Question Answer
Describe the design of an OROS controlled release tablet (type used in Adalat OROS) a824ada5-0bb9-4c58-81f6-74fa77be18e9.jpg (image/jpg)
Describe the design of an insoluble matrix tablet (used to produced controlled/extended/sustained release) drug is dispersed in matrix such as wax or polymer that does not dissolve, fluid permeates in and dissolves drug which leeches out (like a sponge) 13103f68-5f35-4e7b-a277-7de7676392b9.jpg (image/jpg)
Cardizem CD capsules are controlled release and are capsules with beads inside. Explain how controlled release is produced Beads in capsule have a polymer membrane which does not dissolve. Fluid enters through this and dissolve drug which diffuses out 6d116430-fd6b-4b98-bff4-f039b41e640a.jpg (image/jpg)
Some cardiovascular drugs are sustained/extended release tablets that are hydrophilic matrix design. Explain how extended/sustained release is produced in this design drug is compressed in mix with hydrophilic polymer which swells/gels in contact with fluid. fluid diffuses across gel and dissolves drug and drug then diffuses out, also some erosion 8ee5b5fa-1fa2-4683-8efe-d6a510f95c03.jpg (image/jpg)