Flashcards
Cocaine/Amph
Cards in this deck (44)
- 1CocaineSouth America, alkaloid from leaves,
- 2why is cocaine chewedweak base,chew lime/ash to make saliva alkaline to promote absorption across membrane of mouth)
- 3cocaine leaves cokaine past.6-1.8% cocaine
80%coke - 4what is done with the alkaloid?Converted to hydrochloric salt, and crystalized
- 5Cocaine HClreadily water soluble, can be taken orally, trans nasaly or by IV
- 6How is crack/rock made?Cocaine HCl and baking soda heated and dried
- 7Speed of cocaine Concentrationiv>smoke>In>oraly
Iv>IN>oral>smoke - 8what happens durring the first hr?peaks then declines (short acting)
- 9cocaine is?lipophilic so it passes through blood brain barrier
- 10What happens when cocaine is smoked?rapidly gets to the brain but, shows lower peripheral venous levels
- 11What happens when cocaine is absorbed by the blood stream?Rapidly broken down by the enzymes in blood and liver
- 12What is the half life of cocaine?.5-1.5hrs
- 13how long does a high from smoking or IV last for coke?30 min, break down down lasts longer
- 14Cocaine blocks the reuptake of?5-HT, NE, *DA, blocks transporter
- 15The effects on _ are most importantDA, for cocaine's stimulating reinforcing and addictive properties
- 16What happens at high doses of cocaine?it inhibits voltage gated sodium channels in axons, so used as local Anesthetic
- 17Craving is Caused by?less DA in synapse want Euphoria
- 182 examples of how cocaine is used as and anestheticprocain (novacain) and lindocain (Xylocain)
- 19Cocain is considered a _sympathomimetic drug:increases heart rate, vasoconstriction, hpertentions, and hypothrmia
- 20low does of cocain vs high doeseslow not a problem, high= heart failure, stroke, intracrannial hemmerage
- 21who becomes cocaine abusers, 8 ball10-15% of intranasal users, and bingers (3days) 150mg
8 ball:3-5 g at 100$ - 22What does Chronic Cocaine exposure do?gives rise to tolerance and sensitization
- 23Example of how chronic use of coain reults in tolerance/sentisitationc+salene>C+c> salene+salene
- 24Amphetamine is a parent compound ofsynthtetic psycostimulnts
- 25What are the 2 forms of amphetamine?l Amphetamine( Benzedrine) and d amphetamine (Dexedrine)
- 26Other forms of Ampetamine are?Methamphetamine, 3-4 mthyl..(MDMA)
- 27All the amphetamins structures are realted to?DA
- 28Ephedrine and Cathinonefound in plants, Eph:used by chinese( reduces appetit and high energy)- for weight loss but banned, brochovasodialator-Amph was devloped from this
- 29Amphetamine is taken?oraly, IV or SC
- 30Describe the absorption through the GI tractslow, 30 minutes for behavioral effect, 2-15 mgs
- 31Methamphetaminemore potent than amphetamine,
"speed, crank go, meth, zip" - 32Meth is taken?orally, snorted, IV or smoked( through a glass pipe or heating aluminum foil (chasing the dragon) like coke
- 33Methamphetimine hydrochloride in crystaline formsuitible for smoking (ice, crystal), inexpensive and addicive
- 34High does/ chronic uses of amphetaminecause psychotic reactions and brain damage
- 35How does Amphetamine work?Presynaptic terminal: sneaks in and spills transmitter(DA and NE) out of the synapse
- 36Amph. are used to treatADHD ( Ritalin is used), have the reverse effect on normal people
- 37MDMAused recreationally, "ecstasy, Adam, XTC", Develped by Merck to "open up" psycotherapists
- 38How does MDMA differ from Amphetamin?enhances the release of 5HT rather than DA and NE,still stimultes DA release but not as much as 5 HT
- 39Effects of MDMAdamages seratonogenic pathways in brain
- 40Amphetamin increases what kind of tone?Sympathetic
- 41How does Amphetmine get in?In the presynaptice termianl in a vessicle, spills NT(DAand NE)
- 42At low doses of Amph: Ritalin for ADHDit has an opposit effect
- 43Cocaine blocks:reuptake of DA and NE
- 44MDMA can also have?CPP with nasty side effects
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- college Bio 36 Flashcards on Cocaine/Amph, created by maxytrejo1 on 19/11/2013.
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